Immune-Mediated Necrotizing Myopathies: Current Landscape

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY Current Neurology and Neuroscience Reports Pub Date : 2024-04-09 DOI:10.1007/s11910-024-01337-y

Christoforos Koumas, Francesco Michelassi

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Abstract

Purpose of Review

Immune-mediated necrotizing myopathy (IMNM), characterized by acute or subacute onset, severe weakness, and elevated creatine kinase levels, poses diagnostic and therapeutic challenges. This article provides a succinct overview of IMNM, including clinical features, diagnostic strategies, and treatment approaches.

Recent Findings

Recent insights highlight the different clinical presentations and therapeutic options of IMNM stratified by autoantibody positivity and type. Additionally, recent findings call into question the reported link between statin use and IMNM.

Summary

This review synthesizes current knowledge on IMNM, emphasizing its distinct clinical features and challenging management. The evolving understanding of IMNM underscores the need for a comprehensive diagnostic approach that utilizes a growing range of modalities. Early and aggressive immunomodulatory therapy remains pivotal. Ongoing research aims to refine diagnostic tools and therapeutic interventions for this challenging muscle disorder, underscoring the importance of advancing our understanding to enhance patient outcomes.

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免疫介导的坏死性肌病：当前形势

综述目的免疫介导的坏死性肌病（IMNM）以急性或亚急性起病、严重虚弱和肌酸激酶水平升高为特征，给诊断和治疗带来了挑战。本文简要概述了 IMNM，包括临床特征、诊断策略和治疗方法。最近的研究结果最近的研究结果强调了 IMNM 不同的临床表现和治疗方案，这些临床表现和治疗方案按自身抗体阳性率和类型进行了分层。此外，最新研究结果还对他汀类药物的使用与 IMNM 之间的联系提出了质疑。摘要本综述综述了目前有关 IMNM 的知识，强调了其独特的临床特征和具有挑战性的治疗方法。人们对 IMNM 的认识在不断发展，这突出表明需要利用越来越多的方法来进行综合诊断。早期积极的免疫调节治疗仍然至关重要。正在进行的研究旨在完善这一具有挑战性的肌肉疾病的诊断工具和治疗干预措施，强调了加深了解以提高患者预后的重要性。

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来源期刊

Current Neurology and Neuroscience Reports 医学-临床神经学

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Neurology and Neuroscience Reports provides in-depth review articles contributed by international experts on the most significant developments in the field. By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to the diagnosis, treatment, management, and prevention of neurological disease and disorders. Presents the views of experts on current advances in neurology and neuroscience Gathers and synthesizes important recent papers on the topic Includes reviews of recently published clinical trials, valuable web sites, and commentaries from well-known figures in the field.