{"title":"The Two Janus Faces of CpRu-Based Deallylation Catalysts and Their Application for in Cellulo Prodrug Uncaging","authors":"Alain Baiyoumy, Robin Vinck, Thomas R. Ward","doi":"10.1002/hlca.202400053","DOIUrl":null,"url":null,"abstract":"<p>In the past 18 years, metal-catalyzed deallylation has proven a useful tool for studying biological processes <i>in cellulo</i> and in the early development of innovative therapeutic catalytic strategies. This reaction is catalyzed by Ru-piano stool complexes and has been reported to be compatible with air, water, and thiol-containing compounds such as glutathione. However, little is known about the true influence of biological components on the outcome of this reaction. The results presented herein reveal that the co-solvent used in the reaction affects the complex's stability and activity in air, while the presence of glutathione contributes to minimizing the formation of <i>N-</i>allylated by-products. In addition, we studied the effect of air on the Ru-catalyzed deallylation. Importantly, we found that, in the presence of air, the complex is deactivated and oxidizes glutathione into its disulfide.</p>","PeriodicalId":12842,"journal":{"name":"Helvetica Chimica Acta","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hlca.202400053","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Helvetica Chimica Acta","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hlca.202400053","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
In the past 18 years, metal-catalyzed deallylation has proven a useful tool for studying biological processes in cellulo and in the early development of innovative therapeutic catalytic strategies. This reaction is catalyzed by Ru-piano stool complexes and has been reported to be compatible with air, water, and thiol-containing compounds such as glutathione. However, little is known about the true influence of biological components on the outcome of this reaction. The results presented herein reveal that the co-solvent used in the reaction affects the complex's stability and activity in air, while the presence of glutathione contributes to minimizing the formation of N-allylated by-products. In addition, we studied the effect of air on the Ru-catalyzed deallylation. Importantly, we found that, in the presence of air, the complex is deactivated and oxidizes glutathione into its disulfide.
期刊介绍：
Helvetica Chimica Acta, founded by the Swiss Chemical Society in 1917, is a monthly multidisciplinary journal dedicated to the dissemination of knowledge in all disciplines of chemistry (organic, inorganic, physical, technical, theoretical and analytical chemistry) as well as research at the interface with other sciences, where molecular aspects are key to the findings. Helvetica Chimica Acta is committed to the publication of original, high quality papers at the frontier of scientific research. All contributions will be peer reviewed with the highest possible standards and published within 3 months of receipt, with no restriction on the length of the papers and in full color.
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