3D amide proton transfer-weighted imaging may be useful for diagnosing early-stage breast cancer: a prospective monocentric study

Abstract

Background

We investigated the value of three-dimensional amide proton transfer-weighted imaging (3D-APTWI) in the diagnosis of early-stage breast cancer (BC) and its correlation with the immunohistochemical characteristics of malignant lesions.

Methods

Seventy-eight women underwent APTWI and dynamic contrast-enhanced (DCE)-MRI. Pathological results were categorized as either benign (n = 43) or malignant (n = 37) lesions. The parameters of APTWI and DCE-MRI were compared between the benign and malignant groups. The diagnostic value of 3D-APTWI was evaluated using the area under the receiver operating characteristic curve (ROC-AUC) to establish a diagnostic threshold. Pearson’s correlation was used to analyze the correlation between the magnetization transfer asymmetry (MTR_asym) and immunohistochemical characteristics.

Results

The MTR_asym and time-to-peak of malignancies were significantly lower than those of benign lesions (all p < 0.010). The volume transfer constant, rate constant, and wash-in and wash-out rates of malignancies were all significantly greater than those of benign lesions (all p < 0.010). ROC-AUCs of 3D-APTWI, DCE-MRI, and 3D-APTWI+DCE to differential diagnosis between early-stage BC and benign lesions were 0.816, 0.745, and 0.858, respectively. Only the difference between AUC_APT+DCE and AUC_DCE was significant (p < 0.010). When a threshold of MTR_asym for malignancy for 2.42%, the sensitivity and specificity of 3D-APTWI for BC diagnosis were 86.5% and 67.6%, respectively; MTR_asym was modestly positively correlated with pathological grade (r = 0.476, p = 0.003) and Ki-67 (r = 0.419, p = 0.020).

Conclusions

3D-APTWI may be used as a supplementary method for patients with contraindications of DCE-MRI. MTR_asym can imply the proliferation activities of early-stage BC.

Relevance statement

3D-APTWI can be an alternative diagnostic method for patients with early-stage BC who are not suitable for contrast injection.

Key points

• 3D-APTWI reflects the changes in the microenvironment of early-stage breast cancer.

• Combined 3D-APTWI is superior to DCE-MRI alone for early-stage breast cancer diagnosis.

• 3D-APTWI improves the diagnostic accuracy of early-stage breast cancer.

Graphical Abstract