Deep Eutectic System-Based Liquisolid Nanoparticles as Drug Delivery System of Curcumin for In-Vitro Colon Cancer Cells

IF 2.7 4区医学 Q2 PHARMACOLOGY & PHARMACY Journal of Pharmaceutical Innovation Pub Date : 2024-04-09 DOI:10.1007/s12247-024-09826-w

Abdeh Nakaweh, Faisal Al-Akayleh, Mayyas Al-Remawi, Qasem Abdallah, Ahmed S.A. Ali Agha

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Abstract

Purpose

This study aims to improve curcumin’s solubility and anti-cancer effectiveness by utilizing deep eutectic solvents (DES)-based liquisolid nanoparticles. This study aims to develop mesoporous silica nanoparticles (MSNs) containing curcumin and evaluate their therapeutic efficacy against the HCT 116 human colon cancer cell line.

Methods

The study focused on developing different DES formulations using Menthol and Capric Acid, evaluating the effectiveness of surfactants such as Labrasol and Tween 80 in enhancing curcumin dissolution, and synthesizing curcumin-loaded MSNs. The stability of nanoparticles in deep eutectic solvents (DES) and their pharmacological impact on colon cancer cells were thoroughly assessed.

Results

The solubility of curcumin was significantly enhanced through the use of deep eutectic solvent (DES) formulations, specifically when Tween 80 was employed as a surfactant. The in vitro tests showed that curcumin-loaded MSNs with Tween 80 demonstrated strong anti-cancer activity, as indicated by an IC50 value of around 100 µM.

Conclusion

The study effectively shows that DES-based MSNs can greatly improve curcumin’s solubility and anti-cancer effectiveness. Tween 80, as a surfactant, enhances its therapeutic potential, indicating promising prospects for future clinical applications in cancer treatment.

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基于深共晶体系的栗胶纳米颗粒作为姜黄素的体外结肠癌细胞给药系统

目的本研究旨在利用基于深共晶溶剂（DES）的液态固体纳米粒子提高姜黄素的溶解度和抗癌效果。本研究旨在开发含有姜黄素的介孔二氧化硅纳米颗粒（MSNs），并评估其对 HCT 116 人结肠癌细胞系的疗效。研究重点是使用薄荷醇和癸酸开发不同的 DES 配方，评估 Labrasol 和吐温 80 等表面活性剂在提高姜黄素溶解度方面的效果，并合成含有姜黄素的 MSNs。结果通过使用深共晶溶剂（DES）配方，特别是使用吐温 80 作为表面活性剂，姜黄素的溶解度显著提高。体外测试表明，使用 Tween 80 的姜黄素负载 MSN 具有很强的抗癌活性，其 IC50 值约为 100 µM。作为一种表面活性剂，吐温 80 增强了姜黄素的治疗潜力，为未来在癌症治疗领域的临床应用提供了广阔的前景。

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来源期刊

Journal of Pharmaceutical Innovation PHARMACOLOGY & PHARMACY-

CiteScore

3.70

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories: Materials science, Product design, Process design, optimization, automation and control, Facilities; Information management, Regulatory policy and strategy, Supply chain developments , Education and professional development, Journal of Pharmaceutical Innovation publishes four issues a year.