CLINICAL SAMPLING OF SMALL INTESTINE LUMINAL CONTENT FOR MICROBIOME MULTI-OMICS ANALYSIS: A PERFORMANCE ANALYSIS OF THE SMALL INTESTINE MICROBIOME ASPIRATION (SIMBA) CAPSULE AND BENCHMARKING AGAINST ENDOSCOPY
Gang Wang, Cedoljub Bundalovic-Torma, Sharanya Menon, Sabina Bruehlmann, Lynn Wilsack, Renata Rehak, Sahar Bagheri, Mohammad M. Banoei, Lawrence Lou, Yasmin Nasser, Matthew Woo, Ian Lewis, Kathy D. McCoy, Christopher N. Andrews
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Abstract
Objective The small intestine (SI) microbiome is increasingly implicated in both functional gastrointestinal (GI) disorders and a wide range of systemic diseases. However, owing to limitations of traditional GI sampling approaches, the SI remains challenging to directly access on a large scale. This work presents the Small Intestinal MicroBiome Aspiration Capsule (SIMBA) as an effective means for sampling SI luminal content.
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