A novel composite electrode based on graphene oxide/MnO2:h-MoO3 particles for square wave voltammetric determination of acetaminophen

Abstract

A novel composite electrode was developed based on graphene oxide (GO)/MnO₂:h-MoO₃ nanocomposite for sensitive and selective voltammetric detection of acetaminophen (ACP). The composite electrode materials were characterized using X-Ray photoelectron spectroscopy (XPS), X-Ray Diffraction (XRD), scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetric (CV) techniques. In the optimum conditions, the oxidation peak current (I_pa) of ACP was increased linearly with its concentration over two linear ranges from 0.06 to 10.0 μmol L⁻¹ and 20.0 to 80.0 μmol L⁻¹ with a detection limit of 0.0133 μmol L⁻¹. Due to its higher selectivity and long term stability, the composite electrode was applied to the detection of ACP in pharmaceutical formulations.