Effects of anthelmintics on the development of eggs of Angiostrongylus costaricensis in vitro

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-04-12 DOI:10.1017/s0022149x00701532

A. Ishih, M. Yanoh, C. Ikeya, A. Ban, M. Terada

引用次数: 0

Abstract

Effects of the anthelmintics, pyrantel and levamisole, on egg development of Angiostrongylus costaricensis were studied in vitro. After 7 days, about 80% of eggs developed to first-stage larvae in Ham's F-12 medium with 10% foetal calf serum under 5% CO2. Significant inhibition of development was caused by pyrantel (10-9–10-8 g ml-1) and levamisole (10-9–10-8 g ml-1) (Mann-Whitney U-test; P<0.05), and none of the eggs developed to first-stage larvae in higher concentrations of these anthelmintics (10-7 g ml-1). Furthermore, incubation with these drugs at 10-8 g ml-1 for at least 3 h or at 10-4 g ml-1 for 1 h caused irreversible effects on egg development.

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抗蠕虫药对成本角闪尾蛛卵体外发育的影响

在体外研究了吡蚜酮和左旋咪唑这两种抗蠕虫药对科氏疟原虫（Angiostrongylus costaricensis）卵发育的影响。在含有 10%胎牛血清的 Ham's F-12 培养基和 5% CO2 条件下，7 天后，约 80% 的虫卵发育成第一期幼虫。吡蚜酮（10-9-10-8 g ml-1）和左旋咪唑（10-9-10-8 g ml-1）会显著抑制卵的发育（Mann-Whitney U-检验；P<0.05），而在较高浓度（10-7 g ml-1）的抗蠕虫药中，没有卵发育成一级幼虫。此外，用 10-8 g ml-1 的药物孵化至少 3 小时或 10-4 g ml-1 的药物孵化 1 小时都会对卵的发育造成不可逆的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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