A facile microwave-mediated method of 1,4-dihydropyridine carboxylates synthesis by multicomponent reaction

Abstract

An innovative green procedure has been devised to prepare derivatives of 1,4-dihydropyridine (1,4-DHP). This method works with a catalyst process using ethanol as solvent under microwave irradiation conditions, enabling swift reactions (<30 min) with impressive yields (90%–96%). It contributes to an environmentally friendly and easily executable process by using the energy efficiency method. Within 30 min, this method underscores ecologically conscious practices and offers simple purification, streamlining the process by omitting column chromatography. This method highlights the efficacy and eco-friendly nature of synthesizing 1,4-DHPs. This method combines four component reactions, utilizing EtOH as the solvent and triethylamine as the catalyst. Furthermore, the product was characterized by diverse spectroscopic analysis.