The Oral Microbiome in the Development of Oral Cancer

IF 1.5 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Biology Pub Date : 2024-04-09 DOI:10.1134/s0026893324020092
E. S. Kolegova, A. A. Schegoleva, L. A. Kononova, E. V. Denisov
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Abstract—Oral cancer is an aggressive and rapidly progressive disease. The oral cavity is home to over 700 species of microorganisms that regulate metabolism, immune function, and health. There are three types of mechanisms by which bacteria may participate in carcinogenesis. First, bacteria cause chronic inflammation, which stimulates the production of cytokines, including interleukins, interferons, and tumor necrosis factor. Second, bacteria can interact directly with host cells by secreting toxins or by binding to membrane receptors. Finally, the production of metabolites by bacteria may also contribute to carcinogenesis. The importance of the bacteria level and composition in the transition of oral precancerous lesions to cancer has been demonstrated. The relationships of changes in microbiome composition with smoking, inflammation in healthy individuals, as well as with the development of oral cancer in patients, have been studied.

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口腔癌发病过程中的口腔微生物组
摘要--口腔癌是一种侵袭性强、进展迅速的疾病。口腔是 700 多种微生物的家园,它们调节着新陈代谢、免疫功能和健康。细菌参与致癌的机制有三种。首先,细菌会引起慢性炎症,从而刺激细胞因子的产生,包括白细胞介素、干扰素和肿瘤坏死因子。其次,细菌可通过分泌毒素或与膜受体结合直接与宿主细胞相互作用。最后,细菌产生的代谢物也可能导致癌变。细菌水平和组成在口腔癌前病变向癌症转化过程中的重要性已得到证实。微生物组组成的变化与吸烟、健康人的炎症以及患者口腔癌的发展之间的关系已得到研究。
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来源期刊
Molecular Biology
Molecular Biology 生物-生化与分子生物学
CiteScore
1.30
自引率
8.30%
发文量
78
审稿时长
3 months
期刊介绍: Molecular Biology is an international peer reviewed journal that covers a wide scope of problems in molecular, cell and computational biology including genomics, proteomics, bioinformatics, molecular virology and immunology, molecular development biology, molecular evolution and related areals. Molecular Biology publishes reviews, experimental and theoretical works. Every year, the journal publishes special issues devoted to most rapidly developing branches of physical-chemical biology and to the most outstanding scientists.
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