The influence of plant extracts on viability of ST3 and ST7 subtypes of Blastocystis sp.

IF 4.3 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Gut Pathogens Pub Date : 2024-04-03 DOI:10.1186/s13099-024-00613-z

Karolina Kot, Adam Michaliszyn, Elżbieta Kalisińska, Małgorzata Lepczyńska

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Abstract

Blastocystis sp. is one of the most frequently detected protozoa during stool specimen examination. In the last decade, the studies about the pathogenic potential of Blastocystis sp. have intensified. Additionally, treatment approaches against this parasite are still disputable. The study aimed to investigate the in vitro activity of the substances of natural origin against two subtypes (ST) of Blastocystis sp.—ST3 and ST7. Garlic and turmeric extracts exhibited the highest inhibitory effect in relation to the ST3 viability. While horseradish and turmeric were found to be the most effective extracts to the ST7 viability. The study showed that ginger, garlic, horseradish, and turmeric extracts have potent antimicrobial activity against Blastocystis ST3 and ST7, with the half-maximal inhibitory concentration (IC50) ranging from 3.8 to 4.8 µg/ml and from 3.3 to 72.0 µg/ml, respectively, and thus may be useful in the prevention and control of Blastocystis infections. Additionally, this research confirmed that Blastocystis ST7 is more resistant to the selected plant extracts treatment than Blastocystis ST3 which in consequence may bring some difficulties in its eradication.

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植物提取物对布氏杆菌 ST3 和 ST7 亚型活力的影响

大肠囊虫是粪便标本检查中最常发现的原生动物之一。在过去十年中，有关 Blastocystis sp.致病潜能的研究不断加强。此外，针对这种寄生虫的治疗方法仍存在争议。本研究旨在调查天然物质对两种亚型（ST）--ST3 和 ST7 的体外活性。大蒜和姜黄提取物对 ST3 的活力具有最高的抑制作用。而辣根和姜黄提取物对 ST7 的活力最有效。研究表明，生姜、大蒜、辣根和姜黄提取物对布氏杆菌 ST3 和 ST7 具有很强的抗菌活性，其半最大抑制浓度（IC50）分别为 3.8 至 4.8 µg/ml 和 3.3 至 72.0 µg/ml，因此可用于布氏杆菌感染的预防和控制。此外，这项研究还证实，与 ST3 型布氏杆菌相比，ST7 型布氏杆菌对所选植物提取物的抗药性更强，这可能会给根除布氏杆菌带来一些困难。

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来源期刊

Gut Pathogens GASTROENTEROLOGY & HEPATOLOGY-MICROBIOLOGY

CiteScore

7.70

自引率

2.40%

发文量

期刊介绍： Gut Pathogens is a fast publishing, inclusive and prominent international journal which recognizes the need for a publishing platform uniquely tailored to reflect the full breadth of research in the biology and medicine of pathogens, commensals and functional microbiota of the gut. The journal publishes basic, clinical and cutting-edge research on all aspects of the above mentioned organisms including probiotic bacteria and yeasts and their products. The scope also covers the related ecology, molecular genetics, physiology and epidemiology of these microbes. The journal actively invites timely reports on the novel aspects of genomics, metagenomics, microbiota profiling and systems biology. Gut Pathogens will also consider, at the discretion of the editors, descriptive studies identifying a new genome sequence of a gut microbe or a series of related microbes (such as those obtained from new hosts, niches, settings, outbreaks and epidemics) and those obtained from single or multiple hosts at one or different time points (chronological evolution).