HDACi vorinostat protects muscle from degeneration after acute rotator cuff injury in mice.

IF 4.7 2区 医学 Q2 CELL & TISSUE ENGINEERING Bone & Joint Research Pub Date : 2024-04-15 DOI:10.1302/2046-3758.134.bjr-2023-0292.r1
Lara Gil-Melgosa, Rafael Llombart-Blanco, Leire Extramiana, Isabel Lacave, Gloria Abizanda, Estibaliz Miranda, Xabier Agirre, Felipe Prósper, Antonio Pineda-Lucena, Juan Pons-Villanueva, Ana Pérez-Ruiz
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Abstract

Rotator cuff (RC) injuries are characterized by tendon rupture, muscle atrophy, retraction, and fatty infiltration, which increase injury severity and jeopardize adequate tendon repair. Epigenetic drugs, such as histone deacetylase inhibitors (HDACis), possess the capacity to redefine the molecular signature of cells, and they may have the potential to inhibit the transformation of the fibro-adipogenic progenitors (FAPs) within the skeletal muscle into adipocyte-like cells, concurrently enhancing the myogenic potential of the satellite cells.
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HDACi vorinostat 可保护小鼠急性肩袖损伤后的肌肉免于退化。
肩袖(RC)损伤的特点是肌腱断裂、肌肉萎缩、回缩和脂肪浸润,这增加了损伤的严重性并危及肌腱的充分修复。组蛋白去乙酰化酶抑制剂(HDACis)等表观遗传学药物具有重新定义细胞分子特征的能力,它们可能有潜力抑制骨骼肌内纤维-脂肪生成祖细胞(FAPs)向脂肪细胞样细胞的转化,同时增强卫星细胞的成肌潜能。
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来源期刊
Bone & Joint Research
Bone & Joint Research CELL & TISSUE ENGINEERING-ORTHOPEDICS
CiteScore
7.40
自引率
23.90%
发文量
156
审稿时长
12 weeks
期刊介绍: The gold open access journal for the musculoskeletal sciences. Included in PubMed and available in PubMed Central.
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