Mild aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL)-type reactions also present in patients with failed knee prostheses.

IF 4.7 2区 医学 Q2 CELL & TISSUE ENGINEERING Bone & Joint Research Pub Date : 2024-04-04 DOI:10.1302/2046-3758.134.bjr-2023-0255.r1
Anni Rajamäki, Lari Lehtovirta, Mika Niemeläinen, Aleksi Reito, Jyrki Parkkinen, Sirpa Peräniemi, Jouko Vepsäläinen, Antti Eskelinen
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Abstract

Metal particles detached from metal-on-metal hip prostheses (MoM-THA) have been shown to cause inflammation and destruction of tissues. To further explore this, we investigated the histopathology (aseptic lymphocyte-dominated vasculitis-associated lesions (ALVAL) score) and metal concentrations of the periprosthetic tissues obtained from patients who underwent revision knee arthroplasty. We also aimed to investigate whether accumulated metal debris was associated with ALVAL-type reactions in the synovium.
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膝关节假体植入失败的患者也会出现轻度无菌性淋巴细胞为主的血管炎相关病变(ALVAL)型反应。
从金属髋关节假体(MoM-THA)上脱落的金属颗粒已被证明会引起炎症和组织破坏。为了进一步探讨这一问题,我们对接受翻修膝关节置换术的患者假体周围组织的组织病理学(无菌性淋巴细胞为主的血管炎相关病变(ALVAL)评分)和金属浓度进行了调查。我们还旨在研究累积的金属碎片是否与滑膜中的 ALVAL 型反应有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Bone & Joint Research
Bone & Joint Research CELL & TISSUE ENGINEERING-ORTHOPEDICS
CiteScore
7.40
自引率
23.90%
发文量
156
审稿时长
12 weeks
期刊介绍: The gold open access journal for the musculoskeletal sciences. Included in PubMed and available in PubMed Central.
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