Lipid Profile Evolution in Graves’ Disease Treated with Titration Regimen of Anti-Thyroid Drugs Versus Block and Replace Regimen

IF 2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM Hormone and Metabolic Research Pub Date : 2024-04-02 DOI:10.1055/a-2281-0911
Ana-Maria Stancu, Oana Pop, Mariana Purice, Corin Badiu
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Abstract

The aim was to compare the lipid profile of patients with GD treated with anti-thyroid drugs (ATDs) using a titration regimen versus a block and replace regimen. This is an 18-month prospective observational study. In this study were included 149 medically treated GD patients, aged+>+18 years. Pregnant women and patients treated with radioactive iodine therapy or partial/total thyroidectomy were excluded. Patients were divided into 2 subgroups: titration (A) and block and replace (B) therapy, according to the ATD regimen used. Thyroid and metabolic profile was measured at baseline and at least one visit during medical treatment. The whole group included 122 (81.87%) females (F) and 27 (18.12%) males (M), ratio F:M=4.5:1. As expected, at the time of diagnosis, thyrotoxic patients were with normal lipid profile. During medical treatment, in patients who achieved euthyroidism, the cholesterol levels increased as follows: in subgroup A: by 52.9 mg/dl (95% CI: 26.4–79.3), p<0.001 for total cholesterol (T-C), by 33.3 mg/dl (95% CI: 10.3–56.3), p=0.007 for low-density lipoprotein cholesterol (LDL-C) and by 11.44 mg/dl (95% CI: 3.08–19.79), p=0.009 for high-density lipoprotein cholesterol (HDL-C); in subgroup B T-C increased by 45.1 mg/dl (95% CI: 22.2–68), p<0.001 and for LDL-C by 33.57 mg/dl (95% CI: 12.72–54.42), p=0.003. No statistically significant increase in triglyceride levels was determined. Medical treatment of hyperthyroidism due to Graves’ disease increased cholesterol levels regardless of the ATD regimen used.

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采用抗甲状腺药物滴定疗法与阻断和替代疗法治疗巴塞杜氏病的血脂变化情况
目的是比较采用滴定疗法和阻断替代疗法治疗抗甲状腺药物(ATD)的广东患者的血脂状况。这是一项为期18个月的前瞻性观察研究。该研究共纳入了149名接受过药物治疗的GD患者,年龄+>+18岁。孕妇和接受过放射性碘治疗或甲状腺部分/全部切除术的患者被排除在外。根据所使用的 ATD 方案,患者被分为两个亚组:滴定疗法(A)和阻断替代疗法(B)。甲状腺和代谢情况在基线和治疗期间的至少一次就诊时进行测量。全组包括 122 名女性(81.87%)和 27 名男性(18.12%),男女比例为 4.5:1。不出所料,甲亢患者在确诊时血脂正常。在药物治疗期间,达到甲状腺功能亢进的患者的胆固醇水平升高如下:A 亚组:升高 52.9 mg/dl (95% CI: 26.4-79.3), p
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来源期刊
Hormone and Metabolic Research
Hormone and Metabolic Research 医学-内分泌学与代谢
CiteScore
3.80
自引率
0.00%
发文量
125
审稿时长
3-8 weeks
期刊介绍: Covering the fields of endocrinology and metabolism from both, a clinical and basic science perspective, this well regarded journal publishes original articles, and short communications on cutting edge topics. Speedy publication time is given high priority, ensuring that endocrinologists worldwide get timely, fast-breaking information as it happens. Hormone and Metabolic Research presents reviews, original papers, and short communications, and includes a section on Innovative Methods. With a preference for experimental over observational studies, this journal disseminates new and reliable experimental data from across the field of endocrinology and metabolism to researchers, scientists and doctors world-wide.
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