Preregistered analytic plan: the gut microbiome and acute kidney injury in sepsis

Katherine M. Winner, Rishi Chanderraj, Ying He, Mark Nuppnau, Robert J. Woods, Michael Heung, Jennifer A. Schaub, Michael W. Sjoding, Robert P. Dickson
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Abstract

Overview We here share a pre-registered analytic plan for a matched case-control study nested in a retrospective cohort of hospitalized patients with suspected sepsis. We will compare gut microbiota (measured near the time of admission) among patients with sepsis who do and do not develop sepsis-induced acute kidney injury.
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预先登记的分析计划:脓毒症中的肠道微生物组和急性肾损伤
概述 我们在此分享一项预先登记的分析计划,这是一项嵌套于疑似脓毒症住院患者回顾性队列中的匹配病例对照研究。我们将比较脓毒症患者中发生和未发生脓毒症诱发急性肾损伤的肠道微生物群(在入院时测量)。
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