Revival of Bioengineered Proteins as Carriers for Nucleic Acids

IF 3.9 2区 化学 Q1 BIOCHEMICAL RESEARCH METHODS Bioconjugate Chemistry Pub Date : 2024-04-15 DOI:10.1021/acs.bioconjchem.4c00079
David Scherer, Michael Burger* and Jean-Christophe Leroux*, 
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生物工程蛋白质作为核酸载体的复兴
图 1.纳米载体压实核酸,使其不受体液影响,并允许其被靶细胞转运和吸收(A)。载体的内吞可以自发发生,也可以由细胞受体诱导(B)。随后,核酸必须逃离内质体才能到达细胞质(C、D)。最后,DNA 需要受到保护并被输送到细胞核(E)。由 BioRender.com 制作。感谢欧盟地平线 2020 研究与创新计划下的欧洲研究理事会(ERC)提供的资金(拨款号:884505)。本文引用了 78 篇其他出版物。本文尚未被其他出版物引用。图 1.纳米载体压实核酸,使其不受体液影响,并允许其被靶细胞转运和吸收(A)。载体的内吞可以自发发生,也可以由细胞受体诱导(B)。随后,核酸必须逃离内质体才能到达细胞质(C、D)。最后,DNA 需要受到保护并被输送到细胞核(E)。用 BioRender.com 制作。本文参考了 78 篇其他出版物。
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来源期刊
Bioconjugate Chemistry
Bioconjugate Chemistry 生物-化学综合
CiteScore
9.00
自引率
2.10%
发文量
236
审稿时长
1.4 months
期刊介绍: Bioconjugate Chemistry invites original contributions on all research at the interface between man-made and biological materials. The mission of the journal is to communicate to advances in fields including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Bioconjugate Chemistry is intended to provide a forum for presentation of research relevant to all aspects of bioconjugates, including the preparation, properties and applications of biomolecular conjugates.
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