{"title":"Activation Strategies for Alkyl Precursors in Achieving C(sp3)–C(sp3) Cross-Coupling via Metallaphotoredox Catalysis","authors":"Sun Dongbang","doi":"10.1021/acs.organomet.3c00537","DOIUrl":null,"url":null,"abstract":"C(sp<sup>3</sup>)–C(sp<sup>3</sup>) bond formation is gaining more prominence, especially with a growing emphasis on building three-dimensional chemical space in bioactive molecules, fine chemicals, and agrichemicals. Metallaphotoredox catalysis has emerged as an effective strategy for designing processes using diverse C(sp<sup>3</sup>) precursors well suited for 1e<sup>–</sup> radical chemistry. This review summarizes the latest advancement in metallaphotoredox catalysis, addressing the long-standing challenges in C(sp<sup>3</sup>)–C(sp<sup>3</sup>) cross-coupling, with a focus on the classification of reactions based on the distinct modes of activation of C(sp<sup>3</sup>) precursor upon entering the catalytic cycle.","PeriodicalId":56,"journal":{"name":"Organometallics","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organometallics","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acs.organomet.3c00537","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
C(sp3)–C(sp3) bond formation is gaining more prominence, especially with a growing emphasis on building three-dimensional chemical space in bioactive molecules, fine chemicals, and agrichemicals. Metallaphotoredox catalysis has emerged as an effective strategy for designing processes using diverse C(sp3) precursors well suited for 1e– radical chemistry. This review summarizes the latest advancement in metallaphotoredox catalysis, addressing the long-standing challenges in C(sp3)–C(sp3) cross-coupling, with a focus on the classification of reactions based on the distinct modes of activation of C(sp3) precursor upon entering the catalytic cycle.
期刊介绍:
Organometallics is the flagship journal of organometallic chemistry and records progress in one of the most active fields of science, bridging organic and inorganic chemistry. The journal publishes Articles, Communications, Reviews, and Tutorials (instructional overviews) that depict research on the synthesis, structure, bonding, chemical reactivity, and reaction mechanisms for a variety of applications, including catalyst design and catalytic processes; main-group, transition-metal, and lanthanide and actinide metal chemistry; synthetic aspects of polymer science and materials science; and bioorganometallic chemistry.