Pulmonary Transit Time Assessment by CEUS in Healthy Rabbits: Feasibility, and the Effects of UCAs Dilution Concentration

IF 2.5 4区 医学 Q1 ACOUSTICS Ultrasonic Imaging Pub Date : 2024-04-16 DOI:10.1177/01617346241246169
Song Kang, Jianfeng Chen, He Zhang, Guangyin Li, Yingying Liu, Xue Mei, Binyang Zhu, Xin Ai, Shuangquan Jiang
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Abstract

To evaluate the inter-observer variability and the intra-observer repeatability of pulmonary transit time (PTT) measurement using contrast-enhanced ultrasound (CEUS) in healthy rabbits, and assess the effects of dilution concentration of ultrasound contrast agents (UCAs) on PTT. Thirteen healthy rabbits were selected, and five concentrations UCAs of 1:200, 1:100, 1:50, 1:10, and 1:1 were injected into the right ear vein. Five digital loops were obtained from the apical 4-chamber view. Four sonographers obtained PTT by plotting the TIC of right atrium (RA) and left atrium (LA) at two time points (T1 and T2). The frame counts of the first appearance of UCAs in RA and LA had excellent inter-observer agreement, with intra-class correlations (ICC) of 0.996, 0.988, respectively. The agreement of PTT among four observers was all good at five different concentrations, with an ICC of 0.758–0.873. The reproducibility of PTT obtained by four observers at T1 and T2 was performed well, with ICC of 0.888–0.961. The median inter-observer variability across 13 rabbits was 6.5% and the median variability within 14 days for 4 observers was 1.9%, 1.7%, 2.2%, 1.9%, respectively; The PTT of 13 healthy rabbits is 1.01 ± 0.18 second. The difference of PTT between five concentrations is statistically significant. The PTT obtained by a concentration of 1:200 and 1:100 were higher than that of 1:1, while there were no significantly differences in PTT of a concentration of 1:1, 1:10, and 1:50. PTT measured by CEUS in rabbits is feasible, with excellent inter-observer and intra-observer reliability and reproducibility, and dilution concentration of UCAs influences PTT results.
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用 CEUS 评估健康兔子的肺通气时间:可行性和 UCAs 稀释浓度的影响
目的:评估健康兔子使用造影剂增强超声(CEUS)测量肺转运时间(PTT)的观察者间变异性和观察者内重复性,并评估超声造影剂(UCA)稀释浓度对PTT的影响。选取 13 只健康兔子,将 1:200、1:100、1:50、1:10 和 1:1 五种浓度的 UCA 注入右耳静脉。从心尖四腔切面获取五个数字环。四名超声技师通过绘制右心房(RA)和左心房(LA)在两个时间点(T1 和 T2)的 TIC 图来获取 PTT。RA 和 LA 首次出现 UCA 的帧计数在观察者之间具有极好的一致性,类内相关性(ICC)分别为 0.996 和 0.988。在五种不同浓度下,四位观察者的 PTT 一致性都很好,ICC 为 0.758-0.873。四位观察者在 T1 和 T2 阶段获得的 PTT 重现性良好,ICC 为 0.888-0.961。13 只兔子的观察者间变异性中位数为 6.5%,4 名观察者在 14 天内的变异性中位数分别为 1.9%、1.7%、2.2% 和 1.9%;13 只健康兔子的 PTT 为 1.01 ± 0.18 秒。五种浓度之间的 PTT 差异具有统计学意义。浓度为 1:200 和 1:100 的 PTT 均高于 1:1 的 PTT,而浓度为 1:1、1:10 和 1:50 的 PTT 无明显差异。用 CEUS 测量家兔的 PTT 是可行的,具有良好的观察者间和观察者内可靠性和再现性,UCA 的稀释浓度会影响 PTT 结果。
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来源期刊
Ultrasonic Imaging
Ultrasonic Imaging 医学-工程:生物医学
CiteScore
5.10
自引率
8.70%
发文量
15
审稿时长
>12 weeks
期刊介绍: Ultrasonic Imaging provides rapid publication for original and exceptional papers concerned with the development and application of ultrasonic-imaging technology. Ultrasonic Imaging publishes articles in the following areas: theoretical and experimental aspects of advanced methods and instrumentation for imaging
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