Concentrations and influencing factors of 17 elements in placenta, cord blood, and maternal blood of women from an e-waste recycling area

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Trace Elements in Medicine and Biology Pub Date : 2024-04-12 DOI:10.1016/j.jtemb.2024.127449

Yacui Luo , Haijun Zhang , Fangzhong Gui , Jiayang Fang , Haijiang Lin , Danhong Qiu , Lingfei Ge , Qiong Wang , Peiwei Xu , Jun Tang

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Abstract

Background

The effects of prenatal element exposure on mothers and fetuses have generated concern. Profiles of trace and toxic elements in biological material are urgently desired, especially for women who reside near e-waste recycling facilities. The aim of this study was to investigate elements concentrations in placenta, cord blood, and maternal blood of women and to evaluate the influencing factors.

Methods

A group of 48 women from an e-waste recycling site and a group of 31 women from a non-e-waste recycling site were recruited. Basic characteristics were collected by questionnaire and the concentrations of 17 elements in placenta, cord blood, and maternal blood samples were analyzed by inductively coupled plasma mass spectrometry (ICP-MS). Finally, the generalized linear model regression analysis (GLM) was used to test the association between element concentrations and possible factors.

Results

Compared to the control group, the exposed group had significantly elevated cadmium (Cd), zinc (Zn), nickel (Ni), and antimony (Sb) in placenta, and higher lead (Pb) in maternal blood and cord blood (P<0.05). Sb concentration in maternal blood was significantly lower than in the control group (P<0.05). GLM analysis showed that element concentrations were mainly associated with maternal age [chromium (Cr), iron (Fe), selenium (Se), cobalt (Co), mercury (Hg) in placenta, copper (Cu) in maternal blood], education (Se, Sb in placenta), family income (Cu in maternal blood and Ni in placenta), passive smoking [Cu and Zn in placenta, Pb in maternal blood], and e-waste contact history (Hg in cord blood, Cu, Zn, and Cd in maternal blood).

Conclusions

Women in the e-waste recycling area had higher toxic element levels in the placenta and blood samples. More preventive measures were needed to reduce the risk of element exposure for mothers and fetuses in these areas.

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电子废物回收区妇女胎盘、脐带血和母体血液中 17 种元素的浓度及其影响因素

产前接触元素对母亲和胎儿的影响引起了人们的关注。人们急需了解生物材料中微量元素和有毒元素的概况，尤其是居住在电子废物回收设施附近的妇女。本研究旨在调查妇女胎盘、脐带血和母体血液中的元素浓度，并评估影响因素。研究人员招募了来自电子废物回收站的 48 名妇女和来自非电子废物回收站的 31 名妇女。通过问卷调查收集了妇女的基本特征，并采用电感耦合等离子体质谱法（ICP-MS）分析了胎盘、脐带血和母体血液样本中 17 种元素的浓度。最后，利用广义线性模型回归分析（GLM）检验了元素浓度与可能因素之间的关联。与对照组相比，暴露组胎盘中的镉（Cd）、锌（Zn）、镍（Ni）和锑（Sb）明显升高，母血和脐带血中的铅（Pb）也较高（P<0.05）。母血中锑的浓度明显低于对照组（<0.05）。GLM 分析表明，元素浓度主要与母亲年龄[铬（Cr）、铁（Fe）、硒（Se）、钴（Co）、胎盘中的汞（Hg）、母亲血液中的铜（Cu）]、教育程度（Se、胎盘中的硒、锑）、家庭收入（母体血液中的铜和胎盘中的镍）、被动吸烟[胎盘中的铜和锌，母体血液中的铅]以及电子废物接触史（脐带血中的汞、母体血液中的铜、锌和镉）。电子废物回收区的妇女胎盘和血液样本中的有毒元素含量较高。需要采取更多的预防措施，以降低这些地区的母亲和胎儿接触元素的风险。

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.