An exhaustive ADDIS principle for online FWER control

IF 1.3 3区 生物学 Q4 MATHEMATICAL & COMPUTATIONAL BIOLOGY Biometrical Journal Pub Date : 2024-04-18 DOI:10.1002/bimj.202300237
Lasse Fischer, Marta Bofill Roig, Werner Brannath
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Abstract

In this paper, we consider online multiple testing with familywise error rate (FWER) control, where the probability of committing at least one type I error will remain under control while testing a possibly infinite sequence of hypotheses over time. Currently, adaptive-discard (ADDIS) procedures seem to be the most promising online procedures with FWER control in terms of power. Now, our main contribution is a uniform improvement of the ADDIS principle and thus of all ADDIS procedures. This means, the methods we propose reject as least as much hypotheses as ADDIS procedures and in some cases even more, while maintaining FWER control. In addition, we show that there is no other FWER controlling procedure that enlarges the event of rejecting any hypothesis. Finally, we apply the new principle to derive uniform improvements of the ADDIS-Spending and ADDIS-Graph.

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在线 FWER 控制的详尽 ADDIS 原理
在本文中,我们考虑了具有族向误差率(FWER)控制的在线多重检验,即在一段时间内对可能是无限序列的假设进行检验时,犯至少一个 I 型错误的概率将保持在可控范围内。目前,自适应丢弃(ADDIS)程序似乎是在功率方面最有希望实现 FWER 控制的在线程序。现在,我们的主要贡献是统一改进了 ADDIS 原理,从而改进了所有 ADDIS 程序。这意味着,我们提出的方法在保持 FWER 控制的同时,拒绝的假设至少与 ADDIS 程序一样多,在某些情况下甚至更多。此外,我们还证明,没有任何其他 FWER 控制程序能扩大拒绝任何假设的概率。最后,我们应用新原理推导出 ADDIS-Spending 和 ADDIS-Graph 的统一改进。
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来源期刊
Biometrical Journal
Biometrical Journal 生物-数学与计算生物学
CiteScore
3.20
自引率
5.90%
发文量
119
审稿时长
6-12 weeks
期刊介绍: Biometrical Journal publishes papers on statistical methods and their applications in life sciences including medicine, environmental sciences and agriculture. Methodological developments should be motivated by an interesting and relevant problem from these areas. Ideally the manuscript should include a description of the problem and a section detailing the application of the new methodology to the problem. Case studies, review articles and letters to the editors are also welcome. Papers containing only extensive mathematical theory are not suitable for publication in Biometrical Journal.
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