Metagenomic Next-Generation Sequencing Contributes to the Early Diagnosis of Mixed Infections in Central Nervous System

IF 3.6 3区生物学 Q2 MYCOLOGY Mycopathologia Pub Date : 2024-04-18 DOI:10.1007/s11046-024-00837-2

Li Lin, Junyue Fang, Jiahao Li, Ying Tang, Tengteng Xin, Nengtai Ouyang, Wenying Cai, Lisi Xie, Sha Lu, Junmin Zhang

引用次数: 0

Abstract

Central nervous system (CNS) infections represent a challenge due to the complexities associated with their diagnosis and treatment, resulting in a high incidence rate and mortality. Here, we presented a case of CNS mixed infection involving Candida and human cytomegalovirus (HCMV), successfully diagnosed through macrogenomic next-generation sequencing (mNGS) in China. A comprehensive review and discussion of previously reported cases were also provided. Our study emphasizes the critical role of early pathogen identification facilitated by mNGS, underscoring its significance. Notably, the integration of mNGS with traditional methods significantly enhances the diagnostic accuracy of CNS infections. This integrated approach has the potential to provide valuable insights for clinical practice, facilitating early diagnosis, allowing for treatment adjustments, and ultimately, improving the prognosis for patients with CNS infections.

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元基因组下一代测序有助于中枢神经系统混合感染的早期诊断

中枢神经系统（CNS）感染是一项挑战，因为其诊断和治疗非常复杂，导致发病率和死亡率居高不下。在这里，我们介绍了一例在中国通过宏基因组下一代测序（mNGS）成功确诊的念珠菌和人类巨细胞病毒（HCMV）中枢神经系统混合感染病例。研究还对之前报道的病例进行了全面回顾和讨论。我们的研究强调了 mNGS 在早期病原体识别中的关键作用，突出了其重要性。值得注意的是，mNGS 与传统方法的结合大大提高了中枢神经系统感染的诊断准确性。这种整合方法有望为临床实践提供宝贵的见解，促进早期诊断，调整治疗方案，最终改善中枢神经系统感染患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mycopathologia 生物-真菌学

CiteScore

6.80

自引率

3.60%

发文量

审稿时长

3 months

期刊介绍： Mycopathologia is an official journal of the International Union of Microbiological Societies (IUMS). Mycopathologia was founded in 1938 with the mission to ‘diffuse the understanding of fungal diseases in man and animals among mycologists’. Many of the milestones discoveries in the field of medical mycology have been communicated through the pages of this journal. Mycopathologia covers a diverse, interdisciplinary range of topics that is unique in breadth and depth. The journal publishes peer-reviewed, original articles highlighting important developments concerning medically important fungi and fungal diseases. The journal highlights important developments in fungal systematics and taxonomy, laboratory diagnosis of fungal infections, antifungal drugs, clinical presentation and treatment, and epidemiology of fungal diseases globally. Timely opinion articles, mini-reviews, and other communications are usually invited at the discretion of the editorial board. Unique case reports highlighting unprecedented progress in the diagnosis and treatment of fungal infections, are published in every issue of the journal. MycopathologiaIMAGE is another regular feature for a brief clinical report of potential interest to a mixed audience of physicians and laboratory scientists. MycopathologiaGENOME is designed for the rapid publication of new genomes of human and animal pathogenic fungi using a checklist-based, standardized format.