The Impact of Behavioral Lifestyle Intervention on Inflammatory Cytokines in Older Adults Living With Type 2 Diabetes: A Feasibility Study

IF 1.7 4区医学 Q3 HEALTH CARE SCIENCES & SERVICES Inquiry-The Journal of Health Care Organization Provision and Financing Pub Date : 2024-04-20 DOI:10.1177/00469580241248126

Rozmin Jiwani, Monica Serra, Sara Espinoza, Andrea Berndt, Darpan Patel

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Abstract

Objective:This study investigates the effects of a behavioral lifestyle intervention on inflammatory cytokines and frailty in older adults (≥ 65 years) with type 2 diabetes (T2D).Method:We conducted a single-arm, 6-month intervention supplemented with diet and activity self-monitoring technology. We assessed frailty using Fried criteria and quantified inflammatory cytokines (interleukin [IL]-2, IL-4, IL-6, IL-8, IL-10, granulocyte-macrophage colony-stimulating-factor [GM-CSF], interferon [IFN-γ], tumor necrosis factor [TNF-α]) using a multiplex assay. We used paired t-tests with significance at P < .05. We calculated the Spearman correlation and evaluated the relationship between frailty, BMI, and inflammatory cytokines.Results:Eighteen participants completed the study (mean ± SD: 71.5 ± 5.3 years; BMI: 34 ± 6 kg/m2). At baseline, we had 4 frail, 13 pre-frail, and 1 non-frail participant. At 6 months, we observed the therapeutic effects of the intervention on frailty score, BMI, IL-2, IFN-y, and GM-CSF.Discussion:The study highlights the importance of behavioral lifestyle intervention in improving inflammatory cytokines and frailty in older adults.

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行为生活方式干预对 2 型糖尿病老年患者炎性细胞因子的影响：可行性研究

目的：本研究探讨了行为生活方式干预对患有 2 型糖尿病（T2D）的老年人（≥ 65 岁）的炎性细胞因子和虚弱的影响。方法：我们开展了一项为期 6 个月的单臂干预，并辅以饮食和活动自我监测技术。我们采用弗里德标准对虚弱程度进行了评估，并使用多重检测法对炎症细胞因子（白细胞介素 [IL]-2、IL-4、IL-6、IL-8、IL-10、粒细胞-巨噬细胞集落刺激因子 [GM-CSF]、干扰素 [IFN-γ]、肿瘤坏死因子 [TNF-α]）进行了量化。我们采用配对 t 检验，显著性为 P <.05。我们计算了斯皮尔曼相关性，并评估了虚弱、体重指数和炎症细胞因子之间的关系。结果：18 名参与者完成了研究（平均值±标准差：71.5±5.3 岁；体重指数：34±6 kg/m2）。在基线期，我们有 4 名体弱者、13 名前期体弱者和 1 名非体弱者。6 个月后，我们观察到干预对虚弱评分、BMI、IL-2、IFN-y 和 GM-CSF 的治疗效果。讨论：该研究强调了行为生活方式干预对改善老年人炎症细胞因子和虚弱的重要性。

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来源期刊

Inquiry-The Journal of Health Care Organization Provision and Financing 医学-卫生保健

CiteScore

2.50

自引率

0.00%

发文量

192

审稿时长

>12 weeks

期刊介绍： INQUIRY is a peer-reviewed open access journal whose msision is to to improve health by sharing research spanning health care, including public health, health services, and health policy.