Circulating Tumor Cells and Thromboembolic Events in Patients with Glioblastoma

Christina C. Rolling, Malte Mohme, Carsten Bokemeyer, Manfred Westphal, Sabine Riethdorf, Katrin Lamszus, Klaus Pantel, Felix Klingler, Florian Langer
{"title":"Circulating Tumor Cells and Thromboembolic Events in Patients with Glioblastoma","authors":"Christina C. Rolling, Malte Mohme, Carsten Bokemeyer, Manfred Westphal, Sabine Riethdorf, Katrin Lamszus, Klaus Pantel, Felix Klingler, Florian Langer","doi":"10.1055/a-2251-6766","DOIUrl":null,"url":null,"abstract":"<p>Patients with glioblastoma (GBM) are at increased risk for arterial and venous thromboembolism (TE). Risk factors include surgery, the use of corticosteroids, radiation, and chemotherapy, but also prothrombotic characteristics of the tumor itself such as expression of tissue factor, vascular endothelial growth factor, or podoplanin. Although distant metastases are extremely rare in this tumor entity, circulating tumor cells (CTCs) have been detected in a significant proportion of GBM patients, potentially linking local tumor growth characteristics to systemic hypercoagulability. We performed post hoc analysis of a study, in which GBM patients had been investigated for CTCs. Information on TE was retrieved from electronic patient charts. In total, 133 patients (median age, 63 years; interquartile range, 53–70 years) were analyzed. During follow-up, TE was documented in 14 patients (11%), including 8 venous and 6 arterial events. CTCs were detected in 26 patients (20%). Four (15%) patients with CTCs had a TE compared with 10 (9%) patients without CTCs. There was no difference in the frequency of TE events between patients with and those without detectable CTCs (<i>p</i> = 0.58). In summary, although our study confirms a high risk of TE in GBM patients, it does not point to an obvious association between CTCs and vascular thrombosis.</p> ","PeriodicalId":501645,"journal":{"name":"Hämostaseologie","volume":"201 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hämostaseologie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/a-2251-6766","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Patients with glioblastoma (GBM) are at increased risk for arterial and venous thromboembolism (TE). Risk factors include surgery, the use of corticosteroids, radiation, and chemotherapy, but also prothrombotic characteristics of the tumor itself such as expression of tissue factor, vascular endothelial growth factor, or podoplanin. Although distant metastases are extremely rare in this tumor entity, circulating tumor cells (CTCs) have been detected in a significant proportion of GBM patients, potentially linking local tumor growth characteristics to systemic hypercoagulability. We performed post hoc analysis of a study, in which GBM patients had been investigated for CTCs. Information on TE was retrieved from electronic patient charts. In total, 133 patients (median age, 63 years; interquartile range, 53–70 years) were analyzed. During follow-up, TE was documented in 14 patients (11%), including 8 venous and 6 arterial events. CTCs were detected in 26 patients (20%). Four (15%) patients with CTCs had a TE compared with 10 (9%) patients without CTCs. There was no difference in the frequency of TE events between patients with and those without detectable CTCs (p = 0.58). In summary, although our study confirms a high risk of TE in GBM patients, it does not point to an obvious association between CTCs and vascular thrombosis.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
胶质母细胞瘤患者的循环肿瘤细胞与血栓栓塞事件
胶质母细胞瘤(GBM)患者发生动脉和静脉血栓栓塞症(TE)的风险增加。风险因素包括手术、使用皮质类固醇、放疗和化疗,以及肿瘤本身的促血栓形成特征,如组织因子、血管内皮生长因子或 podoplanin 的表达。虽然在这种肿瘤实体中远处转移极为罕见,但在相当一部分 GBM 患者中检测到了循环肿瘤细胞(CTC),这可能将局部肿瘤生长特征与全身高凝状态联系起来。我们对一项研究进行了事后分析,该研究对 GBM 患者进行了 CTCs 调查。我们从电子病历中检索了有关 TE 的信息。共分析了 133 名患者(中位年龄 63 岁;四分位数区间 53-70 岁)。在随访期间,有 14 名患者(11%)记录到 TE,其中包括 8 例静脉事件和 6 例动脉事件。26名患者(20%)检测到了四氯化碳。与 10 例(9%)无 CTC 的患者相比,4 例(15%)有 CTC 的患者发生了 TE。检测到和未检测到 CTCs 的患者发生 TE 事件的频率没有差异(p = 0.58)。总之,尽管我们的研究证实了 GBM 患者发生 TE 的风险很高,但并没有指出 CTC 与血管血栓之间存在明显的关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Perioperative Management for Port Catheter Procedures in Pediatric Patients with Severe Hemophilia and Inhibitors Reform des Kapitels 32 (Laboratoriumsmedizin) im einheitlichen Bewertungsmaßstab (EBM) Pulmonary Embolism: An Update Based on the Revised AWMF-S2k Guideline Efgartigimod hilft bei Immunthrombozytopenie Recurrent Venous Thromboembolism in Patients on Anticoagulation: An Update Based on the Revised AWMF S2k Guideline
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1