Development of Magnetic Resonance Imaging (MRI) Phantom With Arbitrary T1 Value Using Dextrin Hydrate

IF 1.1 4区 物理与天体物理 Q4 PHYSICS, ATOMIC, MOLECULAR & CHEMICAL Applied Magnetic Resonance Pub Date : 2024-04-21 DOI:10.1007/s00723-024-01655-x
Yusuke Sato, Daiki Ito, Norio Hayashi, Kouichi Ujita, Takayuki Suto, Haruyuki Watanabe, Yoshito Tsushima
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Abstract

To formulate the relationship between the dextrin hydrate concentration and T1 relaxation rate and create a magnetic resonance imaging (MRI) phantom with an arbitrary T1 value. Dextrin solution with nine different concentrations was prepared by dissolving 0–20 g (2.5 g increments) of dextrin in 25 g of purified water. The T1 values of the phantoms were measured using a 1.5 T MR scanner, and the relationship between the R1 value and dextrin concentration was regressed using linear and quadratic equations. Phantoms with concentrations adjusted to T1 values of 500, 1000, and 1500 ms were created from each regression equation, and the errors between the measured T1 and target values were evaluated. In addition, the temporal changes in the T1 and T2 values of the phantoms were also evaluated. The T1 and T2 values ranged from 367.4 ± 14.1 to 2577.6 ± 76.5 ms and 20.0 ± 0.9 to 1805.3 ± 8.3 ms, respectively. The linear and quadratic regression equations were \(y=2.9631x+0.2043\) and \(y=1.8295{x}^{2}+1.4995x+0.37\), with coefficients of determination of 0.9763 and 0.9954, respectively. The maximum errors were 12.3% and 2.1% for the linear and quadratic equations, respectively. The T1 value was maintained at a fluctuation rate of approximately 10% during the first 4 weeks. The T2 value decreased by approximately 20% after 4 weeks. MRI phantoms with arbitrary T1 values in the range of 500–1500 ms with an error within 2.1% can be created using dextrin, which can be used as human tissue-equivalent MRI phantoms for T1 of the grey or white matter of the brain, liver, pancreas, spleen, and prostate.

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利用糊精水合物开发具有任意 T1 值的磁共振成像(MRI)模型
制定糊精水合物浓度与 T1 弛豫速率之间的关系,并创建一个具有任意 T1 值的磁共振成像(MRI)模型。将 0-20 克(增量为 2.5 克)糊精溶解在 25 克纯净水中,制备出九种不同浓度的糊精溶液。使用 1.5 T MR 扫描仪测量了模型的 T1 值,并使用线性方程和二次方程对 R1 值与糊精浓度之间的关系进行了回归。根据每个回归方程创建了浓度调整为 500、1000 和 1500 毫秒 T1 值的模型,并评估了测量的 T1 值与目标值之间的误差。此外,还评估了模型 T1 和 T2 值的时间变化。T1 和 T2 值的范围分别为 367.4 ± 14.1 至 2577.6 ± 76.5 ms 和 20.0 ± 0.9 至 1805.3 ± 8.3 ms。线性和二次回归方程分别为(y=2.9631x+0.2043\)和(y=1.8295{x}^{2}+1.4995x+0.37\),决定系数分别为 0.9763 和 0.9954。线性方程和二次方程的最大误差分别为 12.3% 和 2.1%。在最初的 4 周内,T1 值的波动率保持在 10%左右。4 周后,T2 值下降了约 20%。使用糊精可制作出 T1 值在 500-1500 毫秒范围内的任意磁共振成像模型,误差在 2.1% 以内,可用作大脑、肝脏、胰腺、脾脏和前列腺灰质或白质 T1 的人体组织等效磁共振成像模型。
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来源期刊
Applied Magnetic Resonance
Applied Magnetic Resonance 物理-光谱学
CiteScore
1.90
自引率
10.00%
发文量
59
审稿时长
2.3 months
期刊介绍: Applied Magnetic Resonance provides an international forum for the application of magnetic resonance in physics, chemistry, biology, medicine, geochemistry, ecology, engineering, and related fields. The contents include articles with a strong emphasis on new applications, and on new experimental methods. Additional features include book reviews and Letters to the Editor.
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