A Simple Approach to Preparation of Surfactant Nano-Micelles Loaded Drugs

Abstract

The ability to formulate optimum drug-loaded carriers is a challenge that impedes virtuous drug delivery and stability. Nano micelles (NMs) are highly prospective carriers due to their minute dimensions and exceptional biocompatibility. This study investigated a more efficient and straightforward fabrication method for surfactant nano micelles than the conventional solvent vaporization process. The objective was to develop and validate the Direct Method, an expedited approach for producing surfactant NMs. Tween 20, was employed to simulate the solubility of various drugs in Surfactant, including azithromycin monohydrate, fusidic acid, and metronidazole. Four distinct concentrations of the medication were employed. The polydispersity index and micellar diameter were employed to compare and contrast the two methodologies. No significant differences (p < 0.05) were observed between the outcomes obtained from both methods, irrespective of the concentrations of the drugs. The Direct Method exhibited comparable levels of efficiency to the conventional approach. The study effectively established the Direct Method as a rapid and efficient substitute for surfactant NMs synthesis.