Effect of overweight/obesity on relationship between fractional exhaled nitric oxide and airway hyperresponsiveness in Chinese elderly patients with asthma

Fengjia Chen, Yangli Liu, Long-hua Sun, Zhimin Zeng, Xinyan Huang
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Abstract

Purpose: This retrospective study investigates the influence of overweight and obesity status on pulmonary function, airway inflammatory markers, and airway responsiveness in elderly asthma patients. Methods: Patients with asthma older than 65 years old who completed a bronchial provocation test (BPT) or bronchial dilation test (BDT) and a fractional exhaled nitric oxide (FeNO) test between December 2015 and June 2020 were identified retrospectively for this study. All of the patients were categorized into overweight/obesity and non-obesity groups based on their BMI. Pulmonary function test (PFT) and FeNO measurements were accomplished according to the 2014 recommendations of the Chinese National Guidelines of Pulmonary Function Test and American Thoracic Society/European Respiratory Society recommendations, respectively. Results: A total of 136 patients with an average age of 71.2 ± 5.40 years were identified. The average BMI was 23.8 ± 3.63, while the value of FeNO was 42.3 ± 38.4 parts per billion (ppb). In contrast to the non-obesity group, which had a value of 48.8 ± 43.1 ppb for FeNO, the overweight/obesity group had a significant lower value of 35.4 ± 31.4 ppb. There was no significant difference in the proportion of individuals with high airway hyperresponsiveness between the overweight/obesity and non-obesity groups (96 patients in total). Multiple linear regression analysis established an inverse correlation between FeNO and Provocation concentration causing a 20% fall in FEV1(PC20) but excluded significant relationships with age and BMI. The model’s R is 0.289, and its p value is 0.045. Conclusion: The elderly Chinese Han asthmatics with overweight/obesity had lower FeNO levels than those with non-obese according to our findings. In addition, the FeNO level was inversely correlated between FeNO levels and PC20 in elderly asthmatics.
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超重/肥胖对中国老年哮喘患者呼出一氧化氮分数与气道高反应性关系的影响
目的:这项回顾性研究探讨了超重和肥胖状态对老年哮喘患者肺功能、气道炎症标志物和气道反应性的影响。研究方法本研究通过回顾性研究确定了在 2015 年 12 月至 2020 年 6 月期间完成支气管激发试验(BPT)或支气管扩张试验(BDT)和分数呼出一氧化氮(FeNO)试验的 65 岁以上哮喘患者。根据体重指数将所有患者分为超重/肥胖组和非肥胖组。肺功能测试(PFT)和 FeNO 测量分别根据 2014 年《中国肺功能测试国家指南》建议和美国胸科学会/欧洲呼吸学会建议完成。结果共发现 136 名患者,平均年龄(71.2±5.40)岁。平均体重指数为(23.8±3.63),而 FeNO 值为(42.3±38.4)十亿分之一(ppb)。非肥胖组的 FeNO 值为 48.8 ± 43.1 ppb,相比之下,超重/肥胖组的 FeNO 值明显较低,为 35.4 ± 31.4 ppb。超重/肥胖组和非肥胖组(共 96 名患者)气道高反应性的比例没有明显差异。多元线性回归分析确定了 FeNO 与导致 FEV1 下降 20% 的刺激浓度(PC20)之间的反相关性,但排除了与年龄和体重指数之间的显著关系。模型的 R 值为 0.289,P 值为 0.045。结论根据我们的研究结果,超重/肥胖的中国汉族老年哮喘患者的 FeNO 水平低于非肥胖者。此外,老年哮喘患者的 FeNO 水平与 PC20 呈反相关。
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来源期刊
CiteScore
4.00
自引率
0.00%
发文量
88
审稿时长
15 weeks
期刊介绍: International Journal of Immunopathology and Pharmacology is an Open Access peer-reviewed journal publishing original papers describing research in the fields of immunology, pathology and pharmacology. The intention is that the journal should reflect both the experimental and clinical aspects of immunology as well as advances in the understanding of the pathology and pharmacology of the immune system.
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