Spatial genomics: mapping human steatotic liver disease

IF 45.9 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-04-23 DOI:10.1038/s41575-024-00915-2
Kylie P. Matchett, Jasmin Paris, Sarah A. Teichmann, Neil C. Henderson
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Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as non-alcoholic fatty liver disease) is a leading cause of chronic liver disease worldwide. MASLD can progress to metabolic dysfunction-associated steatohepatitis (MASH, formerly known as non-alcoholic steatohepatitis) with subsequent liver cirrhosis and hepatocellular carcinoma formation. The advent of current technologies such as single-cell and single-nuclei RNA sequencing have transformed our understanding of the liver in homeostasis and disease. The next frontier is contextualizing this single-cell information in its native spatial orientation. This understanding will markedly accelerate discovery science in hepatology, resulting in a further step-change in our knowledge of liver biology and pathobiology. In this Review, we discuss up-to-date knowledge of MASLD development and progression and how the burgeoning field of spatial genomics is driving exciting new developments in our understanding of human liver disease pathogenesis and therapeutic target identification. This Perspective discusses single-cell and single-nuclei RNA sequencing in metabolic dysfunction-associated steatotic liver disease and explains how our understanding of the pathology of the disease will accelerate following the advances in spatial transcriptomics.

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空间基因组学:绘制人类脂肪肝地图
代谢功能障碍相关性脂肪性肝病(MASLD,以前称为非酒精性脂肪肝)是全球慢性肝病的主要病因。代谢性脂肪性肝病可发展为代谢功能障碍相关性脂肪性肝炎(MASH,以前称为非酒精性脂肪性肝炎),继而形成肝硬化和肝细胞癌。单细胞和单核 RNA 测序等现有技术的出现改变了我们对肝脏平衡和疾病的认识。下一个前沿领域是将这些单细胞信息在其原始空间方位上进行上下文关联。这种理解将显著加速肝脏学的发现科学,从而进一步改变我们对肝脏生物学和病理生物学的认识。在这篇综述中,我们将讨论有关 MASLD 发展和进展的最新知识,以及蓬勃发展的空间基因组学领域如何推动我们对人类肝病发病机制和治疗靶点识别的认识取得令人兴奋的新进展。
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来源期刊
CiteScore
52.30
自引率
0.60%
发文量
147
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.
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