The impact of Toxocara-seropositivity on attention and motor skills in children with attention-deficit hyperactivity disorder

IF 2.2 3区医学 Q2 OBSTETRICS & GYNECOLOGY Early human development Pub Date : 2024-04-22 DOI:10.1016/j.earlhumdev.2024.106017

Mustafa Tolga Tunagur , Hatice Aksu , Evren Tileklioğlu , Hatice Ertabaklar

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Abstract

Background

The study aims to compare neurological soft signs and executive functions between Toxocara-seropositive and seronegative groups in children with attention-deficit/hyperactivity disorder.

Methods

The study included 60 boys with ADHD, aged 7–12. After blood samples were taken, the Stroop Color Word Test and Judgment of Line Orientation test (JLOT) were implemented to measure executive functions. Neurological soft signs were evaluated with Physical and Neurological Examination for Subtle Signs (PANESS).

Results

Serological tests were positive for Toxocara antibodies in 20 cases. There was no significant difference between Toxocara seropositive and seronegative regarding age, socioeconomic status, developmental stages, and ADHD severity. However, Toxocara-seropositive children had higher Stroop time and Stroop interference scores and lower JLOT scores than Toxocara-seronegative children. Furthermore, Toxocara-seropositive children exhibited more neurological soft signs, such as gait and station abnormalities, dysrhythmia, and a longer total time in timed movements compared to Toxocara-seronegative children.

Conclusion

Our study indicates a link between Toxocara-seropositivity and impaired neurological soft signs and executive functions in ADHD. Further research is needed to understand ADHD mechanisms, develop practical treatments considering immunological factors, and thoroughly evaluate how Toxocara seropositivity affects executive functions and motor skills in children with ADHD.

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弓形虫血清阳性对注意力缺陷多动障碍儿童的注意力和运动技能的影响

背景本研究旨在比较毒鼠强血清反应阳性组和血清反应阴性组注意力缺陷/多动障碍儿童的神经系统软体征和执行功能。抽取血液样本后，采用斯特罗普颜色词测试和直线定向判断测试（JLOT）来测量执行功能。结果20例患者的血清学检测结果为弓形虫抗体阳性。在年龄、社会经济地位、发育阶段和多动症严重程度方面，弓形虫血清阳性和血清阴性之间没有明显差异。然而，与血清反应阴性的儿童相比，弓形虫血清阳性儿童的Stroop时间和Stroop干扰得分更高，JLOT得分更低。此外，与弓形虫血清反应阴性的儿童相比，弓形虫血清反应阳性的儿童表现出更多的神经系统软体征，如步态和站立异常、节律失调以及定时运动的总时间更长。要了解多动症的发病机制，开发考虑免疫因素的实用治疗方法，并全面评估弓形虫血清阳性如何影响多动症儿童的执行功能和运动技能，还需要进一步的研究。

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来源期刊

Early human development 医学-妇产科学

CiteScore

4.40

自引率

4.00%

发文量

100

审稿时长

46 days

期刊介绍： Established as an authoritative, highly cited voice on early human development, Early Human Development provides a unique opportunity for researchers and clinicians to bridge the communication gap between disciplines. Creating a forum for the productive exchange of ideas concerning early human growth and development, the journal publishes original research and clinical papers with particular emphasis on the continuum between fetal life and the perinatal period; aspects of postnatal growth influenced by early events; and the safeguarding of the quality of human survival. The first comprehensive and interdisciplinary journal in this area of growing importance, Early Human Development offers pertinent contributions to the following subject areas: Fetology; perinatology; pediatrics; growth and development; obstetrics; reproduction and fertility; epidemiology; behavioural sciences; nutrition and metabolism; teratology; neurology; brain biology; developmental psychology and screening.