Hyaluronic acid: comprehensive review of a multifunctional biopolymer

IF 3.4 Q2 PHARMACOLOGY & PHARMACY Future Journal of Pharmaceutical Sciences Pub Date : 2024-04-24 DOI:10.1186/s43094-024-00636-y

Abdul Rahim Chethikkattuveli Salih, Hafiz Muhammad Umer Farooqi, Hardik Amin, Pankaj Ranjan Karn, Nileshkumar Meghani, Saraswathy Nagendran

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Abstract

Background

Hyaluronic acid (HA) has a broad range of cosmetic and therapeutic applications due to its unique physicochemical properties and involvement in various essential biological processes, including cell signaling, wound reparation, and tissue regeneration.

Main body

In this review, we provide a comprehensive overview of HA, including its history, physicochemical properties, roles, molecular biology, and biochemistry (including occurrence, biosynthesis, and degradation), as well as its chemical modifications and conventional and emerging production methods. We also examine HA's medical, pharmaceutical, and cosmetic applications and its derivatives in arthrology, ophthalmology, wound healing, odontology, oncology, drug delivery, 3D bioprinting, and cosmetology. Finally, we discuss the potential role of HA in preventing Covid-19.

Conclusion

Hyaluronic acid, a naturally found substance, has shown immense potential in the clinic. Thus, it is imperative to highlight its applications in the diverse fields impacting the lives of patients and healthy individuals.

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透明质酸：多功能生物聚合物综述

背景透明质酸（HA）具有独特的理化特性，并参与各种基本生物过程，包括细胞信号传导、伤口修复和组织再生，因此具有广泛的美容和治疗用途。正文在这篇综述中，我们全面概述了透明质酸，包括其历史、理化特性、作用、分子生物学和生物化学（包括发生、生物合成和降解），以及其化学修饰和传统及新兴生产方法。我们还研究了 HA 在医疗、制药和美容方面的应用，以及它在关节学、眼科学、伤口愈合、牙科学、肿瘤学、药物输送、三维生物打印和美容方面的衍生物。最后，我们讨论了 HA 在预防 Covid-19 方面的潜在作用。因此，必须强调它在影响患者和健康人生活的不同领域中的应用。

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来源期刊

Future Journal of Pharmaceutical Sciences PHARMACOLOGY & PHARMACY-

自引率

0.00%

发文量

审稿时长

23 weeks

期刊介绍： Future Journal of Pharmaceutical Sciences (FJPS) is the official journal of the Future University in Egypt. It is a peer-reviewed, open access journal which publishes original research articles, review articles and case studies on all aspects of pharmaceutical sciences and technologies, pharmacy practice and related clinical aspects, and pharmacy education. The journal publishes articles covering developments in drug absorption and metabolism, pharmacokinetics and dynamics, drug delivery systems, drug targeting and nano-technology. It also covers development of new systems, methods and techniques in pharmacy education and practice. The scope of the journal also extends to cover advancements in toxicology, cell and molecular biology, biomedical research, clinical and pharmaceutical microbiology, pharmaceutical biotechnology, medicinal chemistry, phytochemistry and nutraceuticals.