Anticipating noxious stimulation rather than afferent nociceptive input may evoke pupil asymmetry

IF 3.2 4区 医学 Q2 NEUROSCIENCES Autonomic Neuroscience-Basic & Clinical Pub Date : 2024-04-23 DOI:10.1016/j.autneu.2024.103179
Peter D. Drummond
{"title":"Anticipating noxious stimulation rather than afferent nociceptive input may evoke pupil asymmetry","authors":"Peter D. Drummond","doi":"10.1016/j.autneu.2024.103179","DOIUrl":null,"url":null,"abstract":"<div><p>Unilateral nociceptive stimulation is associated with subtle signs of pupil asymmetry that may reflect lateralized activity in the locus coeruleus. To explore drivers of this pupil asymmetry, electrical stimuli, delivered alone or 200 ms before or after an acoustic startle stimulus, were administered to one ankle under four experimental conditions: with or without a 1.6 s anticipatory period, or while the forearm ipsilateral or contralateral to the electrical stimulus was heated tonically to induce moderate pain (15 healthy participants in each condition). Pupil diameter was measured at the start of each trial, at stimulus delivery, and each second for 5 s after stimulus delivery. At the start of the first trial, the pupil ipsilateral to the side on which electric shocks were later delivered was larger than the contralateral pupil. Both pupils dilated robustly during the anticipatory period and dilated further during single- and dual-stimulus trials. However, pupil asymmetry persisted throughout the experiment. Tonically-applied forearm heat-pain modulated the pupillary response to phasic electrical stimuli, with a slight trend for dilatation to be greater contralateral to the forearm being heated. Together, these findings suggest that focusing anxiously on the expected site of noxious stimulation was associated with dilatation of the ipsilateral pupil whereas phasic nociceptive stimuli and psychological arousal triggered bilateral pupillary dilatation. It was concluded that preparatory cognitive activity rather than phasic afferent nociceptive input is associated with pupillary signs of lateralized activity in the locus coeruleus.</p></div>","PeriodicalId":55410,"journal":{"name":"Autonomic Neuroscience-Basic & Clinical","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S156607022400033X/pdfft?md5=21513025dc81f1652e126082e9632970&pid=1-s2.0-S156607022400033X-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Autonomic Neuroscience-Basic & Clinical","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S156607022400033X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Unilateral nociceptive stimulation is associated with subtle signs of pupil asymmetry that may reflect lateralized activity in the locus coeruleus. To explore drivers of this pupil asymmetry, electrical stimuli, delivered alone or 200 ms before or after an acoustic startle stimulus, were administered to one ankle under four experimental conditions: with or without a 1.6 s anticipatory period, or while the forearm ipsilateral or contralateral to the electrical stimulus was heated tonically to induce moderate pain (15 healthy participants in each condition). Pupil diameter was measured at the start of each trial, at stimulus delivery, and each second for 5 s after stimulus delivery. At the start of the first trial, the pupil ipsilateral to the side on which electric shocks were later delivered was larger than the contralateral pupil. Both pupils dilated robustly during the anticipatory period and dilated further during single- and dual-stimulus trials. However, pupil asymmetry persisted throughout the experiment. Tonically-applied forearm heat-pain modulated the pupillary response to phasic electrical stimuli, with a slight trend for dilatation to be greater contralateral to the forearm being heated. Together, these findings suggest that focusing anxiously on the expected site of noxious stimulation was associated with dilatation of the ipsilateral pupil whereas phasic nociceptive stimuli and psychological arousal triggered bilateral pupillary dilatation. It was concluded that preparatory cognitive activity rather than phasic afferent nociceptive input is associated with pupillary signs of lateralized activity in the locus coeruleus.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
预期有害刺激而非传入痛觉输入可能会诱发瞳孔不对称
单侧痛觉刺激与瞳孔不对称的微妙迹象有关,而瞳孔不对称可能反映了神经中枢的侧向活动。为了探究这种瞳孔不对称的驱动因素,我们在四种实验条件下对一只脚踝进行了电刺激(单独刺激或在声学惊吓刺激前后 200 毫秒刺激):有或没有 1.6 秒的预期时间,或在电刺激的同侧或对侧前臂被加热以诱发中度疼痛时(每种条件下有 15 名健康参与者)。瞳孔直径在每次试验开始时、刺激发出时以及刺激发出后 5 秒钟内每秒测量一次。在第一次试验开始时,随后发出电击的同侧瞳孔大于对侧瞳孔。在预期期间,两侧瞳孔都强烈放大,并在单刺激和双刺激试验期间进一步放大。然而,瞳孔不对称现象在整个实验过程中持续存在。前臂热痛调节了瞳孔对阶段性电刺激的反应,在前臂被加热的对侧,瞳孔扩张的趋势更明显。这些发现共同表明,焦虑地关注预期的有害刺激部位与同侧瞳孔扩张有关,而相位痛觉刺激和心理唤醒会引发双侧瞳孔扩张。结论是准备性认知活动而非阶段性传入痛觉输入与瞳孔中侧性活动的位置相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
5.80
自引率
7.40%
发文量
83
审稿时长
66 days
期刊介绍: This is an international journal with broad coverage of all aspects of the autonomic nervous system in man and animals. The main areas of interest include the innervation of blood vessels and viscera, autonomic ganglia, efferent and afferent autonomic pathways, and autonomic nuclei and pathways in the central nervous system. The Editors will consider papers that deal with any aspect of the autonomic nervous system, including structure, physiology, pharmacology, biochemistry, development, evolution, ageing, behavioural aspects, integrative role and influence on emotional and physical states of the body. Interdisciplinary studies will be encouraged. Studies dealing with human pathology will be also welcome.
期刊最新文献
Editorial Board Intrasubject reproducibility of supine norepinephrine plasma concentrations in patients with cardiovascular sympathetic failure The role of peripheral venous distension reflex in regulating hemodynamics: mini review Carotid body interoception in health and disease Renal interoception in health and disease
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1