Advanced Sequencing Techniques to Map RNA Methylation

IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Israel Journal of Chemistry Pub Date : 2024-04-26 DOI:10.1002/ijch.202400003
Ge-Ge Song, Xiu Fan, Chun-Chun Gao, Yong-Liang Zhao, Yun-Gui Yang
{"title":"Advanced Sequencing Techniques to Map RNA Methylation","authors":"Ge-Ge Song,&nbsp;Xiu Fan,&nbsp;Chun-Chun Gao,&nbsp;Yong-Liang Zhao,&nbsp;Yun-Gui Yang","doi":"10.1002/ijch.202400003","DOIUrl":null,"url":null,"abstract":"<p>RNA methylation is a crucial epigenetic modification widely present in RNA molecules, and has been demonstrated to play significant roles in diverse biological processes. Advances in detection and sequencing technologies have facilitated the identification of RNA modification-related regulatory proteins and their corresponding biological functions. In this paper, we provide a brief overview of several RNA methylation, including <i>N</i><sup>6</sup>-methyladenosine(m<sup>6</sup>A), 5-methylcytidine(m<sup>5</sup>C), <i>N</i><sup>1</sup>-methyladenosine(m<sup>1</sup>A), <i>N</i><sup>7</sup>-methylguanosine(m<sup>7</sup>G) and <i>N</i><sup>6</sup>, 2’-O-dimethyladenosine(m<sup>6</sup>Am), about their regulatory proteins, distribution patterns and biological functions, and mainly outline the advantages and limitations of the representative sequencing techniques. Finally, we discuss the technological challenges and future perspectives in RNA transcriptomic field.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Israel Journal of Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ijch.202400003","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

RNA methylation is a crucial epigenetic modification widely present in RNA molecules, and has been demonstrated to play significant roles in diverse biological processes. Advances in detection and sequencing technologies have facilitated the identification of RNA modification-related regulatory proteins and their corresponding biological functions. In this paper, we provide a brief overview of several RNA methylation, including N6-methyladenosine(m6A), 5-methylcytidine(m5C), N1-methyladenosine(m1A), N7-methylguanosine(m7G) and N6, 2’-O-dimethyladenosine(m6Am), about their regulatory proteins, distribution patterns and biological functions, and mainly outline the advantages and limitations of the representative sequencing techniques. Finally, we discuss the technological challenges and future perspectives in RNA transcriptomic field.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
绘制 RNA 甲基化图谱的先进测序技术
RNA 甲基化是广泛存在于 RNA 分子中的一种重要的表观遗传修饰,已被证明在多种生物过程中发挥着重要作用。检测和测序技术的进步促进了 RNA 修饰相关调控蛋白及其相应生物学功能的鉴定。本文对 N6-甲基腺苷(m6A)、5-甲基胞苷(m5C)、N1-甲基腺苷(m1A)、N7-甲基鸟苷(m7G)和 N6,2'-O-二甲基腺苷(m6Am)等几种 RNA 甲基化的调控蛋白、分布模式和生物学功能进行了简要概述,并主要概述了代表性测序技术的优势和局限性。最后,我们讨论了 RNA 转录组学领域的技术挑战和未来展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Israel Journal of Chemistry
Israel Journal of Chemistry 化学-化学综合
CiteScore
6.20
自引率
0.00%
发文量
62
审稿时长
6-12 weeks
期刊介绍: The fledgling State of Israel began to publish its scientific activity in 1951 under the general heading of Bulletin of the Research Council of Israel, which quickly split into sections to accommodate various fields in the growing academic community. In 1963, the Bulletin ceased publication and independent journals were born, with Section A becoming the new Israel Journal of Chemistry. The Israel Journal of Chemistry is the official journal of the Israel Chemical Society. Effective from Volume 50 (2010) it is published by Wiley-VCH. The Israel Journal of Chemistry is an international and peer-reviewed publication forum for Special Issues on timely research topics in all fields of chemistry: from biochemistry through organic and inorganic chemistry to polymer, physical and theoretical chemistry, including all interdisciplinary topics. Each topical issue is edited by one or several Guest Editors and primarily contains invited Review articles. Communications and Full Papers may be published occasionally, if they fit with the quality standards of the journal. The publication language is English and the journal is published twelve times a year.
期刊最新文献
Cover Picture: (Isr. J. Chem. 8-9/2024) Special Issue on RNA-Based Catalysts that Revolutionized the Discovery of Bioactive Peptides Hexagonal and Trigonal Quasiperiodic Tilings Breaking the Degeneracy of Sense Codons – How Far Can We Go? Cover Picture: (Isr. J. Chem. 6-7/2024)
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1