Advanced Sequencing Techniques to Map RNA Methylation

IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Israel Journal of Chemistry Pub Date : 2024-04-26 DOI:10.1002/ijch.202400003
Ge-Ge Song, Xiu Fan, Chun-Chun Gao, Yong-Liang Zhao, Yun-Gui Yang
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Abstract

RNA methylation is a crucial epigenetic modification widely present in RNA molecules, and has been demonstrated to play significant roles in diverse biological processes. Advances in detection and sequencing technologies have facilitated the identification of RNA modification-related regulatory proteins and their corresponding biological functions. In this paper, we provide a brief overview of several RNA methylation, including N6-methyladenosine(m6A), 5-methylcytidine(m5C), N1-methyladenosine(m1A), N7-methylguanosine(m7G) and N6, 2’-O-dimethyladenosine(m6Am), about their regulatory proteins, distribution patterns and biological functions, and mainly outline the advantages and limitations of the representative sequencing techniques. Finally, we discuss the technological challenges and future perspectives in RNA transcriptomic field.

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绘制 RNA 甲基化图谱的先进测序技术
RNA 甲基化是广泛存在于 RNA 分子中的一种重要的表观遗传修饰,已被证明在多种生物过程中发挥着重要作用。检测和测序技术的进步促进了 RNA 修饰相关调控蛋白及其相应生物学功能的鉴定。本文对 N6-甲基腺苷(m6A)、5-甲基胞苷(m5C)、N1-甲基腺苷(m1A)、N7-甲基鸟苷(m7G)和 N6,2'-O-二甲基腺苷(m6Am)等几种 RNA 甲基化的调控蛋白、分布模式和生物学功能进行了简要概述,并主要概述了代表性测序技术的优势和局限性。最后,我们讨论了 RNA 转录组学领域的技术挑战和未来展望。
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来源期刊
Israel Journal of Chemistry
Israel Journal of Chemistry 化学-化学综合
CiteScore
6.20
自引率
0.00%
发文量
62
审稿时长
6-12 weeks
期刊介绍: The fledgling State of Israel began to publish its scientific activity in 1951 under the general heading of Bulletin of the Research Council of Israel, which quickly split into sections to accommodate various fields in the growing academic community. In 1963, the Bulletin ceased publication and independent journals were born, with Section A becoming the new Israel Journal of Chemistry. The Israel Journal of Chemistry is the official journal of the Israel Chemical Society. Effective from Volume 50 (2010) it is published by Wiley-VCH. The Israel Journal of Chemistry is an international and peer-reviewed publication forum for Special Issues on timely research topics in all fields of chemistry: from biochemistry through organic and inorganic chemistry to polymer, physical and theoretical chemistry, including all interdisciplinary topics. Each topical issue is edited by one or several Guest Editors and primarily contains invited Review articles. Communications and Full Papers may be published occasionally, if they fit with the quality standards of the journal. The publication language is English and the journal is published twelve times a year.
期刊最新文献
Cover Picture: (Isr. J. Chem. 8-9/2024) Special Issue on RNA-Based Catalysts that Revolutionized the Discovery of Bioactive Peptides Hexagonal and Trigonal Quasiperiodic Tilings Breaking the Degeneracy of Sense Codons – How Far Can We Go? Cover Picture: (Isr. J. Chem. 6-7/2024)
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