Using the tumour microenvironment to improve therapy efficacy

IF 72.5 1区 医学 Q1 ONCOLOGY Nature Reviews Cancer Pub Date : 2024-04-26 DOI:10.1038/s41568-024-00693-8
Zuzana Tatarova
{"title":"Using the tumour microenvironment to improve therapy efficacy","authors":"Zuzana Tatarova","doi":"10.1038/s41568-024-00693-8","DOIUrl":null,"url":null,"abstract":"In this Tools of the Trade article, Zuzana Tatarova describes the development of MIMA, an integrated analytical platform providing the quantitative information on tumour microenvironment drug responses required for effective treatment design.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"24 7","pages":"444-444"},"PeriodicalIF":72.5000,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Cancer","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41568-024-00693-8","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

In this Tools of the Trade article, Zuzana Tatarova describes the development of MIMA, an integrated analytical platform providing the quantitative information on tumour microenvironment drug responses required for effective treatment design.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
利用肿瘤微环境提高疗效
靶向抗癌药和化疗利用了癌细胞的内在弱点。然而,有证据表明,局部肿瘤微环境(TME)可影响肿瘤行为,从而促进或抑制肿瘤生长。针对肿瘤细胞弱点的药物也会影响肿瘤微环境。了解了这些影响,就能开发出既能直接抑制癌细胞,又能对肿瘤微环境产生间接抗癌作用的药物组合。我们开发了多重植入式微装置检测法(MIMA),这是一个综合分析平台,可提供有效治疗设计所需的癌症和TME药物反应定量信息。MIMA 系统可以评估动物模型和人体对药物和药物组合的反应;使用微型植入式微装置进行局部但空间上独立的纳升级药物瘤内给药;使用 30 多种蛋白质的多重免疫染色和定量成像来确定癌症组织中的癌细胞、免疫细胞和基质细胞的类型、分子状态和组织。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Nature Reviews Cancer
Nature Reviews Cancer 医学-肿瘤学
CiteScore
111.90
自引率
0.40%
发文量
97
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Cancer, a part of the Nature Reviews portfolio of journals, aims to be the premier source of reviews and commentaries for the scientific communities it serves. The correct abbreviation for abstracting and indexing purposes is Nat. Rev. Cancer. The international standard serial numbers (ISSN) for Nature Reviews Cancer are 1474-175X (print) and 1474-1768 (online). Unlike other journals, Nature Reviews Cancer does not have an external editorial board. Instead, all editorial decisions are made by a team of full-time professional editors who are PhD-level scientists. The journal publishes Research Highlights, Comments, Reviews, and Perspectives relevant to cancer researchers, ensuring that the articles reach the widest possible audience due to their broad scope.
期刊最新文献
PDX models for functional precision oncology and discovery science Conventional chemotherapy: millions of cures, unresolved therapeutic index Re-envisioning genetic predisposition to childhood and adolescent cancers Lactate gives a sour taste Nanotubes power up T cells
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1