Recent Progress on Targeted Gel Media for the Application of Bioanalysis.

IF 4.2 2区化学 Q1 CHEMISTRY, ANALYTICAL Critical reviews in analytical chemistry Pub Date : 2024-04-25 DOI:10.1080/10408347.2024.2333059

Shouhui Weng, Hanbing Huang, Lu Huang, Zhuomin Zhang

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Abstract

Targeted gels have been attractive and regarded as a kind of promising adsorptive media for bioanalysis due to their advantages of high specific surface area, enough stability, and adjustable porous structure. Recently, targeted gel media have been applied for separation and enrichment of various biomolecules from different biological samples. Moreover, targeted gel media have been introduced into surface-enhanced Raman scattering (SERS) technology to eliminate matrix effect for rapid and accurate analysis of biological samples. In this article, we introduced the preparation methods of targeted gel media including in-situ polymerization method, self-assembly method and one-pot method. Then, the functions of targeted gel media in bioanalysis including separation-enrichment media, SERS substrates, and target-responsive units were also reviewed in detail. Additionally, the applications of targeted gel media for biomarker analysis, bioimaging analysis and cell engineering were further discussed. Finally, we tried to elucidate the trend and perspective into the future landscape of targeted gel media for bioanalysis.

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应用于生物分析的靶向凝胶介质的最新进展。

靶向凝胶具有高比表面积、足够的稳定性和可调节的多孔结构等优点，因此被认为是一种很有前景的生物分析吸附介质。最近，靶向凝胶介质已被用于分离和富集不同生物样品中的各种生物大分子。此外，靶向凝胶介质还被引入到表面增强拉曼散射（SERS）技术中，以消除基质效应，从而快速准确地分析生物样品。本文介绍了靶向凝胶介质的制备方法，包括原位聚合法、自组装法和一锅法。然后，详细介绍了靶向凝胶介质在生物分析中的功能，包括分离富集介质、SERS 基底和靶响应单元。此外，我们还进一步讨论了靶向凝胶介质在生物标记分析、生物成像分析和细胞工程中的应用。最后，我们试图阐明生物分析领域靶向凝胶介质的发展趋势和未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical reviews in analytical chemistry 化学-分析化学

CiteScore

12.00

自引率

4.00%

发文量

137

审稿时长

6 months

期刊介绍： Critical Reviews in Analytical Chemistry continues to be a dependable resource for both the expert and the student by providing in-depth, scholarly, insightful reviews of important topics within the discipline of analytical chemistry and related measurement sciences. The journal exclusively publishes review articles that illuminate the underlying science, that evaluate the field''s status by putting recent developments into proper perspective and context, and that speculate on possible future developments. A limited number of articles are of a "tutorial" format written by experts for scientists seeking introduction or clarification in a new area. This journal serves as a forum for linking various underlying components in broad and interdisciplinary means, while maintaining balance between applied and fundamental research. Topics we are interested in receiving reviews on are the following: · chemical analysis; · instrumentation; · chemometrics; · analytical biochemistry; · medicinal analysis; · forensics; · environmental sciences; · applied physics; · and material science.