Comprehensive Overview of Treponema pallidum Outer Membrane Proteins.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-04-24 DOI:10.2174/0113892037293502240328042224

Sirui Wu, Lan Luo, Fei Ye, Yuanfang Wang, Dongdong Li

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Abstract

Treponema pallidum, the causative agent of syphilis, is a sexually transmitted microorganism that exhibits remarkable motility capabilities, allowing it to affect various systems. Despite its structural resemblance to gram-negative bacteria due to its dual-membrane, T. pallidum possesses a lower abundance of outer membrane proteins (OMPs), which enables it to effectively conceal itself. This review presents a comprehensive analysis of the clinical diagnostic potential associated with the OMPs of T. pallidum. Furthermore, the known OMPs in T. pallidum that are responsible for mediating host interactions have been progressively elucidated. This review aims to shed light on the pathogenesis of syphilis, encompassing aspects such as vascular inflammation, chancre self-healing, neuroinvasion, and reinfection. Additionally, this review offers a detailed overview of the current state and prospects of development in the field of syphilis vaccines, with the ultimate goal of establishing a foundation for understanding the pathogenesis and implementing effective prevention strategies against syphilis.

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苍白螺旋体外膜蛋白综合概述

苍白螺旋体是梅毒的病原体，是一种通过性传播的微生物，具有显著的运动能力，可以影响各种系统。尽管其双膜结构与革兰氏阴性菌相似，但苍白螺旋体拥有较少的外膜蛋白（OMPs），这使其能够有效地隐藏自己。本综述全面分析了与苍白螺旋体外膜蛋白相关的临床诊断潜力。此外，苍白螺旋体中负责介导宿主相互作用的已知 OMPs 也已被逐步阐明。本综述旨在阐明梅毒的发病机制，包括血管炎症、硬下疳自愈、神经入侵和再感染等方面。此外，本综述还详细概述了梅毒疫苗领域的现状和发展前景，最终目的是为了解梅毒的发病机制和实施有效的预防策略奠定基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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