Recurrent disease after pediatric renal transplantation.

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-04-23 DOI:10.1111/petr.14676

Anjali Nayak, R. Ettenger, Katherine Wesseling-Perry

引用次数: 0

Abstract

BACKGROUND Recurrent disease after kidney transplant remains an important cause of allograft failure, accounting for 7-8% of graft loss and ranking as the fifth most common cause of allograft loss in the pediatric population. Although the pathophysiology of many recurrent diseases is incompletely understood, recent advances in basic science and therapeutics are improving outcomes and changing the course of several of these conditions. METHODS Review of the literature. RESULTS We discuss the diagnosis and management of recurrent disease. CONCLUSION We highlight new insights into the pathophysiology and treatment of post-transplant primary hyperoxaluria, focal segmental glomerulosclerosis, immune complex glomerulonephritis, C3 glomerulopathy, lupus nephritis, atypical hemolytic uremic syndrome, and IgA nephropathy.

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小儿肾移植后疾病复发。

背景肾移植后的复发性疾病仍是导致异体移植失败的重要原因，占移植物损失的 7-8%，是儿科人群中导致异体移植失败的第五大常见原因。虽然人们对许多复发性疾病的病理生理学尚不完全了解，但基础科学和治疗学的最新进展正在改善这些疾病的治疗效果并改变其病程。结论我们强调了对移植后原发性高草酸尿症、局灶节段性肾小球硬化症、免疫复合物肾小球肾炎、C3肾小球病、狼疮肾炎、非典型溶血性尿毒症综合征和IgA肾病的病理生理学和治疗的新见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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