Polymorphisms of IL-1B And IL-10 Genes in Abortion Due to Toxoplasmosis

Abstract

Ninety whole blood samples were collected from women attended Ibn-abalady Hospital/Baghdad city. 60 samples were taken from aborted women and 30 samples were taken from healthy women as a control group, from period 1st October 2022 to 2nd may 2023. According the results, the mean age of aborted women who attacked with toxoplasmois groups were 31.50 ±1.05 versus 34.53±2.09 of control groups with non-statistical differences (P-value=0.2). The results also observed the most cases of 3 (30.0%) among  aborted women were at the (27-36) years with 27/60 (73.0%) , while the less cases of  toxoplasmosis among  aborted women were at the age  > 46 years with 3/60 (30.0%),These differences statistically were non-significant (P-value=0.07). The results also observed there were equal cases of toxoplasmosis of women who habited urban and rural regions 30 /60 (66.7%),30 (66.7%) respectively. the levels of IgM (2.01±0.15, 0.13±0.03) and IgG (14.24±0.91, 0.09±0.02)  were higher in levels among pregnant women than control groups respectively, these differences in the levels was highly significant (p ≤0.001,≤ 0.001) respectively. the levels of  IL-IB (24.32±1.04, 4.64±0.36) and IL-10 (60.67±3.46, 5.61±0.36)  were higher in levels among aborted women than control groups respectively, these differences in the levels was highly significant. there were a significant differences in the levels of IgM () among aborted betwen the duration of pregnancy with P-value=0.03,Althogh the  the levels of IgG were  increased in levls among aborted women during the the first, second and third (14.40±1.41, 15.16±1.77, 12.86±1.62) above the normal range (≥1) respectively.  there were non  significant differences in the levels of both IL-1B  and IL-10   among aborted women during the the first, second and third simister although there were increased in the levels of both IL-1B  and IL-10.