Current Understanding of Timing of Surgical Repair for Ventricular Septal Rupture following Acute Myocardial Infarction.

IF 17.7 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-04-20 DOI:10.1159/000538967
Shilin Wang, Hao Liu, Peiwen Yang, Zhiwen Wang, Shu Chen
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Abstract

BACKGROUND Ventricular septal rupture (VSR) is a mechanical issue that can occur following an acute myocardial infarction (AMI) and has a high mortality rate. It requires a comprehensive, team-based approach for prompt diagnosis and maintaining stable blood flow. While the occurrence of VSR has lessened over the past hundred years and advancements have been made in treatment techniques, the mortality rate within 30 days can still surpass 40 percent. Surgery is the primary treatment method. For patients with stable blood flow, it's generally considered safer to perform surgery 4-6 weeks after the AMI to repair the VSR. However, the timing of surgery for patients with early instability in their blood flow is still a topic of debate. SUMMARY There's a lack of set criteria and standards to determine the best time for surgery in patients with VSR following an infarction who have unstable blood flow, especially when considering the use of blood circulation support devices and other techniques for maintaining blood flow that are used in clinical settings. KEY MESSAGES This review outlines the features of different mechanical circulatory support devices utilized in treating VSR, along with the current scoring system designed to direct the treatment approach for VSR patients.
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目前对急性心肌梗死后室间隔破裂手术修复时机的理解。
背景心室间隔破裂(VSR)是急性心肌梗死(AMI)后可能发生的机械性问题,死亡率很高。它需要以团队为基础的综合方法来及时诊断并维持稳定的血流。虽然在过去的一百年里,VSR 的发生率有所降低,治疗技术也取得了进步,但 30 天内的死亡率仍可超过 40%。手术是主要的治疗方法。对于血流稳定的患者,一般认为在急性心肌梗死发生后 4-6 周进行手术修复 VSR 更为安全。摘要对于血流不稳定的心梗后 VSR 患者,尤其是考虑到临床上使用的血液循环支持装置和其他维持血流的技术,目前还缺乏确定最佳手术时间的标准和规范。要点 本综述概述了用于治疗 VSR 的不同机械循环支持装置的特点,以及目前旨在指导 VSR 患者治疗方法的评分系统。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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