Multifunctional Deep Eutectic Solvent-Catalyzed Synthesis of Dihydropyrimidinethiones: A Sustainable Approach for Green and Efficient Reactions

IF 0.9 Q4 CHEMISTRY, PHYSICAL Current Organocatalysis Pub Date : 2024-04-19 DOI:10.2174/0122133372302803240415045313

A. Khandebharad, Satyanaryan M. Arde, Shrutika C. Pardeshi, Bharat K. Dhotre, S. Sarda

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Abstract

This study investigates the synthesis of dihydropyrimidinethiones using a multifunctional deep eutectic solvent (DES) composed of Choline chloride (ChCl) and ammonium thiocyanate. This DES serves as a catalyst, solvent, and reagent, providing a simple, highyielding, and environmentally friendly method for dihydropyrimidinethione synthesis. The use of DES in this capacity offers several advantages, including reduced environmental impact, high efficiency, and ease of use, highlighting its potential as a sustainable alternative in organic synthesis. The objective of this study is to investigate the application of a deep eutectic solvent (DES) composed of ChCl and ammonium thiocyanate as a catalytic solvent and reagent system for synthesizing dihydropyrimidinethiones. The aim is to simplify the reaction setup, improve yields, and enhance the green metrics of the process. ChCl and ammonium thiocyanate were combined to form a DES catalyst-solvent system. Dihydropyrimidinethiones were synthesized in one-pot reactions at ambient temperature. Green metrics and DES recovery were evaluated. Comparative analysis with traditional methods was conducted. The DES efficiently catalyzed dihydropyrimidinethione synthesis with high yields. Simplified reaction setup, safe solvent properties, and favorable green metrics. DES was recoverable and reusable, outperforming traditional methods in efficiency and eco-friendliness. The ChCl and ammonium thiocyanate DES demonstrated remarkable efficiency and eco-friendliness in dihydropyrimidinethione synthesis. The toxicity-free, multifunctional roles of the DES, serving as a catalyst, solvent, and reagent, highlight its novelty and potential as a sustainable alternative in organic chemistry. This study simplifies the synthesis process and improves yields and green metrics, showcasing the DES as a promising candidate for future research and industrial applications.

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多功能深共晶溶剂催化合成二氢嘧啶硫醚：实现绿色高效反应的可持续方法

本研究探讨了使用由氯化胆碱（ChCl）和硫氰酸铵组成的多功能深共晶溶剂（DES）合成二氢嘧啶硫醚的方法。这种 DES 可用作催化剂、溶剂和试剂，为二氢嘧啶硫酮的合成提供了一种简单、高产和环保的方法。本研究的目的是研究由 ChCl 和硫氰酸铵组成的深共晶溶剂（DES）作为催化溶剂和试剂系统合成二氢嘧啶硫酮的应用。将氯化 ChCl 和硫氰酸铵组合成 DES 催化剂-溶剂体系，在常温下通过一锅反应合成二氢嘧啶硫醚。对绿色指标和 DES 回收率进行了评估，并与传统方法进行了比较分析。简化的反应设置、安全的溶剂特性以及良好的绿色指标。氯化 ChCl 和硫氰酸铵 DES 在二氢嘧啶硫酮合成中表现出显著的效率和生态友好性。作为催化剂、溶剂和试剂，DES 的无毒性和多功能性凸显了其作为有机化学可持续替代品的新颖性和潜力。这项研究简化了合成过程，提高了产率和绿色指标，展示了 DES 在未来研究和工业应用中的前景。

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来源期刊

Current Organocatalysis CHEMISTRY, PHYSICAL-

CiteScore

2.00

自引率

0.00%

发文量

期刊介绍： Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.