{"title":"Circadian marker in duodenal ulcer","authors":"E. M. Esedov, L. N. Musaeva","doi":"10.37489/2588-0519-2024-1-86-90","DOIUrl":null,"url":null,"abstract":"The purpose. To study the content of melatonin in venous blood, to assess the seasonal variability of the hormone in patients with duodenal ulcer (DU) and to establish a possible relationship between the studied parameters.Material and methods. 45 patients with varying clinical activity of DU during exacerbation and during treatment were examined. Determination of melatonin in venous blood was carried out using high-performance liquid chromatography with tandem mass spectrometry. To assess the condition of the duodenum, fibrogastroduodenoscopy of the gastroduodenal zone we used Exera (cIF160) and Olympus endoscopes.Results. It has been established that in the active stage of DU the levels of the hormone melatonin are reduced. In order to study the possible effect of light illumination on melatonin content, we studied the production of this indole in groups of patients with DU at different times of the year. It turned out that the melatonin content was significantly lower in the group of patients with peptic ulcer disease in winter and spring.Conclusion. The regression and correlation analysis carried out revealed a positive moderate dependence of the melatonin indicator on the duration of daylight hours in the venous blood. Clinical remission of DU after 2 months was accompanied by an increase in melatonin production.","PeriodicalId":326764,"journal":{"name":"Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37489/2588-0519-2024-1-86-90","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The purpose. To study the content of melatonin in venous blood, to assess the seasonal variability of the hormone in patients with duodenal ulcer (DU) and to establish a possible relationship between the studied parameters.Material and methods. 45 patients with varying clinical activity of DU during exacerbation and during treatment were examined. Determination of melatonin in venous blood was carried out using high-performance liquid chromatography with tandem mass spectrometry. To assess the condition of the duodenum, fibrogastroduodenoscopy of the gastroduodenal zone we used Exera (cIF160) and Olympus endoscopes.Results. It has been established that in the active stage of DU the levels of the hormone melatonin are reduced. In order to study the possible effect of light illumination on melatonin content, we studied the production of this indole in groups of patients with DU at different times of the year. It turned out that the melatonin content was significantly lower in the group of patients with peptic ulcer disease in winter and spring.Conclusion. The regression and correlation analysis carried out revealed a positive moderate dependence of the melatonin indicator on the duration of daylight hours in the venous blood. Clinical remission of DU after 2 months was accompanied by an increase in melatonin production.
研究目的研究静脉血中褪黑激素的含量,评估十二指肠溃疡(DU)患者体内褪黑激素的季节性变化,并确定研究参数之间可能存在的关系。研究人员对 45 名十二指肠溃疡患者在病情加重和治疗期间的不同临床活动进行了调查。采用高效液相色谱-串联质谱法测定静脉血中的褪黑激素。为了评估十二指肠的状况,我们使用了Exera(cIF160)和奥林巴斯内窥镜对胃十二指肠区进行纤维胃十二指肠镜检查。已经证实,在 DU 的活动期,荷尔蒙褪黑激素的水平会降低。为了研究光照对褪黑激素含量可能产生的影响,我们研究了一组 DU 患者在一年中不同时期吲哚的分泌情况。结果发现,消化性溃疡病患者组在冬季和春季的褪黑激素含量明显较低。进行的回归和相关分析表明,静脉血中的褪黑激素指标与日照时间的长短呈中度正相关。2 个月后,DU 的临床缓解伴随着褪黑激素分泌的增加。