{"title":"Long-term follow-up of patients developing gastric mucosal lesions after initiating the potassium-competitive acid blocker vonoprazan.","authors":"Kimitoshi Kubo, Noriko Kimura","doi":"10.5946/ce.2023.186","DOIUrl":null,"url":null,"abstract":"Vonoprazan has recently been developed and approved for clinical use in Japan 1 as a drug of the potassium-competitive acid blocker (P-CAB) class reported to reversibly inhibit gastric acid output through K + -competitive ionic binding to H + /K + -ATP- ase. 2 Vonoprazan has been shown to selectively accumulate in gastric parietal cells in the mucosal layer of the rat stomach, 3 and gastric cracked mucosa (GCM), redness, white spots (WS), and gastric polyps (GP) have been reported as P-CAB-asso-ciated gastric mucosal lesions. 4-10 However, only a few cases have demonstrated a causal relationship between vonoprazan and gastric mucosal lesions through long-term follow-up from before drug initiation to after its discontinuation. 5,6 We herein report two cases in which GCM, WS, and GP newly appeared after the initiation of vonoprazan treatment and were followed up after switching to proton pump inhibitors (PPIs). The study protocol was","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" 3","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5946/ce.2023.186","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
Vonoprazan has recently been developed and approved for clinical use in Japan 1 as a drug of the potassium-competitive acid blocker (P-CAB) class reported to reversibly inhibit gastric acid output through K + -competitive ionic binding to H + /K + -ATP- ase. 2 Vonoprazan has been shown to selectively accumulate in gastric parietal cells in the mucosal layer of the rat stomach, 3 and gastric cracked mucosa (GCM), redness, white spots (WS), and gastric polyps (GP) have been reported as P-CAB-asso-ciated gastric mucosal lesions. 4-10 However, only a few cases have demonstrated a causal relationship between vonoprazan and gastric mucosal lesions through long-term follow-up from before drug initiation to after its discontinuation. 5,6 We herein report two cases in which GCM, WS, and GP newly appeared after the initiation of vonoprazan treatment and were followed up after switching to proton pump inhibitors (PPIs). The study protocol was
期刊介绍：
ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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