Meng-Hua Li, Wan-Qi Wang, Li-Ting Zheng, Meng-Bing Chen, Yang Chu, Miao Qiao, Zuo-Li Zhang, Konduru Naveena, Yong Pan, Yun-Shi Zhang, He Sun, Xiao-Hui Ma, Xi Shi
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引用次数: 0
Abstract
This study aimed to explore andrographolide’s mechanism of action and its protective effect on noise-induced hearing loss (NIHL).
A mice animal model for NIHL was established through exposure to broadband noise at 120 dB sound pressure level for 4 h. Transcriptomics analysis and pharmacodynamic experiments were carried out.
Andrographolide enters the inner ear and effectively prevents hearing damage following noise exposure in the mice model for permanent hearing loss. Moreover, treatment with andrographolide inhibited the excessive activation of inflammatory factors in the cochleae of noise-exposed mice.
Andrographolide might be a promising candidate for auditory protective drug investigation.
期刊介绍：
ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.
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