The Therapeutic Potency of Silver/Chitosan, Silver/Saponin and Chitosan/ Saponin Nanocomposites on Ethanol-induced Gastric Ulcers in Wistar Rats.

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-04-16 DOI:10.2174/0127722708283559240405075921

Maha Ahmed Taha Hassan, Amel M Soliman, Ayman Saber Mohamed

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Abstract

BACKGROUND The annual incidence of peptic ulcer disease is estimated to be four million cases worldwide, with an average lifetime risk of 7.5% in individuals of all ages. Polymer nanocomposites have novel prospects in the field of modern medicine. OBJECTIVE The present research endeavors to assess the therapeutic efficacy of nanoparticles composed of silver/chitosan, silver/saponin, and chitosan/saponin against gastric ulcers induced by ethanol in Wistar rats. METHODS Forty-eight rats were randomly split into eight groups of the same size. Oral ethanol (5 ml/kg of body weight) was given to all rat groups except the control one for 1 hour before treatment. Control and ulcer groups of rats were given distilled water orally. The rats in the other groups were given orally 1/10 LD50 of each treatment as follows: AgNPs, chitosan NPs, Saponin, AgNPs-Chitosan NPs, AgNP-Saponin, and chitosan-Saponin NPs. RESULTS NP-treated groups showed a significant increase in the gastric juice pH, glutathione reduced, catalase, and nitric oxide while gastric juice volume, ulcer index, and malondialdehyde levels decreased compared with the ulcer group. Histopathological investigation of stomach showed improvement in NPs groups specially in the chitosan-Saponin NPs group. CONCLUSION The current study revealed that silver-chitosan, silver-saponin and chitosansaponin nanocomposites effectively treat gastric ulcers. Chitosan-Saponin nanoparticles showed high therapeutic effectiveness against gastric ulcer in rats.

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银/壳聚糖、银/皂素和壳聚糖/皂素纳米复合材料对乙醇诱发的 Wistar 大鼠胃溃疡的治疗作用

背景据估计，全世界消化性溃疡病的年发病率为 400 万例，所有年龄段的人一生中患此病的平均风险为 7.5%。本研究试图评估银/壳聚糖、银/皂素和壳聚糖/皂素组成的纳米颗粒对乙醇诱导的 Wistar 大鼠胃溃疡的疗效。除对照组外，其他各组大鼠在治疗前 1 小时均口服乙醇（5 毫升/千克体重）。对照组和溃疡组大鼠口服蒸馏水。其他组的大鼠口服 1/10 LD50 的每种处理，具体如下：结果与溃疡组相比，AgNP 处理组的胃液 pH 值、谷胱甘肽还原酶、过氧化氢酶和一氧化氮含量显著增加，而胃液体积、溃疡指数和丙二醛含量则有所下降。胃的组织病理学检查显示，NPs 组尤其是壳聚糖-皂苷 NPs 组的胃病有所改善。壳聚糖-皂苷纳米粒子对大鼠胃溃疡具有很高的治疗效果。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.