Effects of Selenium Supplementation on Thyroid Nodule Volume in Euthyroid Patients: A Randomized Clinical Trial

IF 0.3 Q4 PHARMACOLOGY & PHARMACY Current Drug Therapy Pub Date : 2024-04-16 DOI:10.2174/0115748855283065240403073316

Zeid Zerehsaz, M. Yaghoubi, Ali Teimouri, Zohreh Mousavi, Mona Najaf Najafi, Ali Moradi, Masoud Mohebbi, A. Sahebkar

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Abstract

Evaluating the Effect of Selenium Supplementation on Thyroid Nodule Volume in Euthyroid Patients Selenium is an essential trace element, which plays a role in regulation of the metabolism of thyroid hormones. This study was designed to evaluate the effect of selenium on the volume of thyroid nodules in euthyroid patients. In this triple-blinded clinical trial, a total of 60 euthyroid patients with benign thyroid nodules (solitary or multinodular goiter) and normal serum selenium were randomly divided into the case and control (n=30 each) groups. The case group received selenium 200 μg/day while the control group received placebo for 3 months. Thyroid ultrasound was used to measure thyroid nodule volume. Selenium supplementation (200 µg/day) retained the serum selenium levels of participants in the case group (P=0.251), while, the control group showed a significant drop in serum selenium levels (P=0.007). Moreover, the thyroid volume in case group showed a significant decrease after selenium supplementation (P=0.012); however, a nonsignificant increase was seen in thyroid volume in control group (P=0.832). Selenium supplementation can reduce thyroid nodule volume in euthyroid patients. Selenium; supplementation; thyroid; thyroid volume; thyroid nodule; euthyroid

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补充硒对甲状腺功能正常患者甲状腺结节体积的影响：随机临床试验

评估补硒对甲状腺功能正常患者甲状腺结节体积的影响硒是人体必需的微量元素，在甲状腺激素代谢中起着调节作用。本研究旨在评估补硒对甲状腺功能正常患者甲状腺结节体积的影响。在这项三盲临床试验中，60 名甲状腺良性结节（单发或多发结节性甲状腺肿）且血清硒含量正常的甲状腺功能正常患者被随机分为病例组和对照组（各 30 人）。病例组每天服用硒200微克，对照组服用安慰剂3个月。硒补充剂（200 微克/天）保持了病例组参与者的血清硒水平（P=0.251），而对照组的血清硒水平显著下降（P=0.007）。此外，病例组的甲状腺体积在补硒后出现了显著下降（P=0.012）；而对照组的甲状腺体积则出现了非显著性增加（P=0.832）。

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Current Drug Therapy PHARMACOLOGY & PHARMACY-

CiteScore

1.30

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0.00%

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期刊介绍： Current Drug Therapy publishes frontier reviews of high quality on all the latest advances in drug therapy covering: new and existing drugs, therapies and medical devices. The journal is essential reading for all researchers and clinicians involved in drug therapy.