Generalised exanthematous pustular dermatophytids during Trichophyton violaceum tinea capitis

Nicolas Kluger
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Abstract

Dermatophytids are defined as the acute occurrence of noninfectious secondary lesions at distance from a primary dermatophytic infection. They are well-known after intertrigo of the toes. We report an 8-year-old boy, who developed generalised pustular lesions during the treatment of tinea capitis caused by Trichophyton violaceum. He had a rapid response to local corticosteroid ointment, while oral terbinafine was efficient on the scalp condition. Dermatophytids are the result of a type IV delayed hypersensitivity reaction to dermatophytic antigens. They may occur after initiation of an antifungal treatment. Generalised exanthematous pustular dermatophytids is a clinical variant of dermatophytids. They present as nonfollicular, nonconfluent pustules with an erythematous base, of abrupt onset. Main differential diagnoses are acute generalised exanthematous pustulosis and pustular psoriasis. Medical history, clinical presentation, laboratory findings and, if necessary, biopsy will help to distinguish between those conditions. Evolution is rapidly favourable under local or oral corticotherapy and antifungal treatments should not be withdrawn. Dermatophytids are a differential diagnostic of acute generalised pustulosis during tinea capitis.

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毛癣菌性头癣期间的全身性泛发性脓疱性皮炎
皮癣是指在原发皮癣感染的基础上急性发生的非感染性继发病变。它们是继足趾间皮瘤之后众所周知的疾病。我们报告了一名 8 岁男孩,他在治疗由毛癣菌引起的头癣期间出现了全身性脓疱病。他对局部皮质类固醇软膏反应迅速,而口服特比萘芬对头皮病症有效。皮癣是对皮癣抗原的 IV 型迟发性超敏反应的结果。它们可能在开始抗真菌治疗后发生。全身泛发性脓疱型皮癣是皮癣的一种临床变异型。它们表现为非叶状、非融合性脓疱,基底红斑,发病突然。主要鉴别诊断为急性泛发性脓疱病和脓疱性银屑病。病史、临床表现、实验室检查结果以及必要时的活组织检查有助于区分这些疾病。在局部或口服皮质类固醇激素治疗后,病情会迅速好转,但不应停止抗真菌治疗。皮肤癣菌是头癣急性全身脓疱病的鉴别诊断依据。
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