Bridging systems biology and tissue engineering: Unleashing the full potential of complex 3D in vitro tissue models of disease.

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-04-10 DOI:10.1063/5.0179125

Jose L. Cadavid, Nancy T. Li, A. McGuigan

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Abstract

Rapid advances in tissue engineering have resulted in more complex and physiologically relevant 3D in vitro tissue models with applications in fundamental biology and therapeutic development. However, the complexity provided by these models is often not leveraged fully due to the reductionist methods used to analyze them. Computational and mathematical models developed in the field of systems biology can address this issue. Yet, traditional systems biology has been mostly applied to simpler in vitro models with little physiological relevance and limited cellular complexity. Therefore, integrating these two inherently interdisciplinary fields can result in new insights and move both disciplines forward. In this review, we provide a systematic overview of how systems biology has been integrated with 3D in vitro tissue models and discuss key application areas where the synergies between both fields have led to important advances with potential translational impact. We then outline key directions for future research and discuss a framework for further integration between fields.

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连接系统生物学和组织工程学：释放复杂三维疾病体外组织模型的全部潜能。

组织工程学的飞速发展使三维体外组织模型变得更加复杂，并与生理相关，可应用于基础生物学和治疗开发。然而，由于分析这些模型所使用的还原论方法，这些模型所提供的复杂性往往没有得到充分利用。系统生物学领域开发的计算和数学模型可以解决这个问题。然而，传统的系统生物学大多应用于较简单的体外模型，生理相关性不强，细胞复杂性有限。因此，将这两个固有的跨学科领域结合起来，可以产生新的见解，推动两个学科向前发展。在这篇综述中，我们系统地概述了系统生物学如何与三维体外组织模型相结合，并讨论了两个领域的协同作用在哪些关键应用领域取得了具有潜在转化影响的重要进展。然后，我们概述了未来研究的主要方向，并讨论了进一步整合两个领域的框架。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.