Platelet Function in Mood Disorders: Interplay, Clinical Implications, and Future Perspectives – A Narrative Review

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-04-10 DOI:10.4103/hm.hm-d-23-00066

Ni He, Hanxiu Liu, Jing Liu, Xiqiang Wang, Junkui Wang, Hengwei Xu, Zhongwei Liu

{"title":"Platelet Function in Mood Disorders: Interplay, Clinical Implications, and Future Perspectives – A Narrative Review","authors":"Ni He, Hanxiu Liu, Jing Liu, Xiqiang Wang, Junkui Wang, Hengwei Xu, Zhongwei Liu","doi":"10.4103/hm.hm-d-23-00066","DOIUrl":null,"url":null,"abstract":"\n Mood disorders, encompassing major depressive disorder and bipolar disorder, present complex etiologies involving neuroanatomical, neurotransmitter, and inflammatory mechanisms. Recent research explores the role of platelets, traditionally associated with hemostasis, in the pathophysiology of mood disorders. We examine neuroanatomical insights, neurotransmitter dysregulation, and the link between inflammation and mood disorders, emphasizing the complex nature of mood disturbances. Emerging evidence of altered platelet function in mood disorders and the therapeutic potential of antiplatelet agents and serotonin reuptake inhibitors are discussed. While personalized medicine holds promise, further research is needed to fully comprehend this evolving field. This review offers comprehensive insights into mood disorder diagnosis, intervention, and pathophysiology. In this review, a comprehensive literature search was conducted using databases such as PubMed, Scopus, and Web of Science. The search focused on articles published from 2000 to 2023, using keywords like “platelet function,” “mood disorders,” and “neurotransmitter dysregulation.” We included studies that specifically investigated the role of platelets in mood disorders, encompassing various study designs and population demographics.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":"191 1‐2","pages":""},"PeriodicalIF":17.7000,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/hm.hm-d-23-00066","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Mood disorders, encompassing major depressive disorder and bipolar disorder, present complex etiologies involving neuroanatomical, neurotransmitter, and inflammatory mechanisms. Recent research explores the role of platelets, traditionally associated with hemostasis, in the pathophysiology of mood disorders. We examine neuroanatomical insights, neurotransmitter dysregulation, and the link between inflammation and mood disorders, emphasizing the complex nature of mood disturbances. Emerging evidence of altered platelet function in mood disorders and the therapeutic potential of antiplatelet agents and serotonin reuptake inhibitors are discussed. While personalized medicine holds promise, further research is needed to fully comprehend this evolving field. This review offers comprehensive insights into mood disorder diagnosis, intervention, and pathophysiology. In this review, a comprehensive literature search was conducted using databases such as PubMed, Scopus, and Web of Science. The search focused on articles published from 2000 to 2023, using keywords like “platelet function,” “mood disorders,” and “neurotransmitter dysregulation.” We included studies that specifically investigated the role of platelets in mood disorders, encompassing various study designs and population demographics.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

情绪障碍中的血小板功能：相互作用、临床意义和未来展望--叙述性综述

情绪障碍包括重度抑郁障碍和双相情感障碍，病因复杂，涉及神经解剖、神经递质和炎症机制。最近的研究探索了传统上与止血相关的血小板在情绪障碍病理生理学中的作用。我们研究了神经解剖学见解、神经递质失调以及炎症与情绪障碍之间的联系，强调了情绪障碍的复杂性。我们还讨论了情绪障碍中血小板功能改变的新证据，以及抗血小板药物和血清素再摄取抑制剂的治疗潜力。虽然个性化医疗前景广阔，但要全面了解这一不断发展的领域，还需要进一步的研究。本综述对情绪障碍的诊断、干预和病理生理学提供了全面的见解。本综述使用 PubMed、Scopus 和 Web of Science 等数据库进行了全面的文献检索。检索的重点是 2000 年至 2023 年发表的文章，使用的关键词包括 "血小板功能"、"情绪障碍 "和 "神经递质失调"。我们收录了专门研究血小板在情绪障碍中作用的研究，包括各种研究设计和人口统计数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

期刊最新文献

Issue Publication Information Issue Editorial Masthead Mapping and Rewiring Biology via Proximity Induction Synthesis, Structure, and Function of Heparan Sulfate Glycopolymers to Investigate Glycosaminoglycan-Protein Interactions. Designing Fullerene-Based Nanomedicines for Treating Inflammatory Diseases: From Molecular Mechanism to Clinical Translation.