Therapeutic Potential, Pharmacological Activities and Analytical Aspects of Liriodendrin in Medicine: Novel and Potential Therapy Options for the Treatment of Human Disorders and Associated Complications

Abstract

Natural products and their derived secondary metabolites play an important role in medicine and other allied health sectors. Liriodendrin is one of the main lignans of Boerhaavia diffusa roots. Liriodendrin is a lignin class phytochemical having numerous health beneficial properties in medicine, including anti-myocardial ischemia, anti-arrhythmic, anti-oxidant and anti- inflammatory potential. This present review aims to analyze the reported ethnomedicinal properties, pharmacological activities and analytical aspects of liriodendrin and identify the remaining gaps in medicinal fields for their future investigations. The pharmacological properties of liriodendrin have been described in the present paper in order to describe its better utilization in natural medicine in the future. Biological poptential and pharmacological activities of liriodendrin have been described in the present work with their analytical development in the scientific fields. In the present work, scientific data on liriodendrin were collected from different scientific databases such as PubMed, Springer, Google, Science Direct, and Google Scholar. They described their biological potential on the basis of the available scientific literature. Further, research and review articles from peer-reviewed journals were also searched during data collection. The present paper's scientific data signified the biological importance of liriodendrin in medicine, which has been isolated from Boerhaavia diffusa and other medicinal plants. Liriodendrin has biological potential against myocardial infarction, arrhythmias, lung injury, hepatic injury, antiinflammatory, ulcerative colitis, gastric injury, SARS-CoV-2 protease and intestinal inflammation. Further, its effectiveness in medicine was also due to its anti-convulsant activity, nitric oxide inhibitory potential, cytotoxicity, cytoprotective nature, anti-oxidant, and anti-microbial potential. The present paper's scientific data also described the metabolism and analytical development for their isolation, separation and identification in different samples. Detailed pharmacological activities of liriodendrin have been described here in the present work and highlighted its important pharmacological properties and analytical aspects. Liriodendrin is a valuable phytochemical of Boerhaavia diffusa, which has numerous biological applications in medicine. Further, this study can also validate the traditional and ethnobotanical use of the Boerhaavia diffusa and other plant material, which contain a significant amount of liriodendrin as an active phytochemical. Liriodendrin have huge biological potential far beyond its traditional uses in human complications.