Ultrasound elastography predicts anticoagulation in lower extremity deep vein thrombosis.

IF 2.1 4区医学 Q3 HEMATOLOGY Clinical hemorheology and microcirculation Pub Date : 2024-04-09 DOI:10.3233/ch-232031

Ao-Yi Zhang, Ya-Xin Dong, Yan-Di Tan, Dian-Shen, Heng-Sun, Shu-Ting Nie, Yuan-Yuan Shao, Feng-Xian, Wen-Shu Hu, Xin-YI Li, Tao-Xu, An-Ni Li, Chang-Zhou, Liang-Xu

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Abstract

OBJECTIVE To investigate predictors of anticoagulation efficacy in deep venous thrombosis (DVT) by ultrasound elastography (UE). METHODS The basic clinical, laboratory and ultrasound treatment data of fifty-eight patients with DVT were collected and analyzed. Then the results of ultrasound after 3-month anticoagulation treatment were compared among different groups. Multiple logistic regression analysis was used to identify independent risk factors that affected anticoagulation efficacy. The predictive efficacy of each independent risk factor was accessed by drawing operating characteristic (ROC) curves. RESULTS According to the regression analysis, the elastic modulus (OR = 0.631, P = 0.001) and strain rate ratio (OR = 0.332, P = 0.006) were identified as independent risk factors for the effectiveness of anticoagulation therapy in patients with DVT. According to the ROC curves, elastic modulus and strain rate ratio could predict effective anticoagulation therapy for DVT, and the optimal threshold values were 22.10 kPa and 1.80 respectively. The corresponding AUC values were 0.879 and 0.854, with a sensitivity of 71.4% and 59.5%, a specificity of 93.7%, and a Youden index of 65.1% and 62.7%, respectively. CONCLUSIONS The elastic modulus (≤22.10 kPa) or strain rate ratio (≤1.80) of the thrombus were independent predictors for the effectiveness of anticoagulation therapy.

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超声弹性成像可预测下肢深静脉血栓的抗凝治疗。

目的：通过超声弹性成像（UE）研究深静脉血栓（DVT）抗凝疗效的预测因素。方法：收集并分析 58 例深静脉血栓患者的基本临床、实验室和超声治疗数据。方法：收集 58 名深静脉血栓患者的基本临床、实验室和超声治疗数据，然后比较不同组别在 3 个月抗凝治疗后的超声结果。采用多元逻辑回归分析找出影响抗凝疗效的独立风险因素。结果根据回归分析，弹性模量（OR = 0.631，P = 0.001）和应变率比（OR = 0.332，P = 0.006）被确定为深静脉血栓患者抗凝疗效的独立危险因素。根据 ROC 曲线，弹性模量和应变率比可预测深静脉血栓的有效抗凝治疗，最佳阈值分别为 22.10 kPa 和 1.80。结论血栓的弹性模量（≤22.10 kPa）或应变率比（≤1.80）是抗凝治疗有效性的独立预测指标。

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来源期刊

Clinical hemorheology and microcirculation 医学-外周血管病

CiteScore

4.30

自引率

33.30%

发文量

170

期刊介绍： Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research. The endeavour of the Editors-in-Chief and publishers of Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process. Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.