The Role of Long Non-Coding RNAs in Vascular Smooth Muscle Cell Phenotype and the Pathogenesis of Cardiovascular and Cerebrovascular Aneurysms

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-04-09 DOI:10.1097/fjc.0000000000001575

Hao-wei Deng, Zi-ming Ye, Rui-ting Hu, Chao Qin

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Abstract

Aneurysms are localized dilations of blood vessels, which can expand to 50% of the original diameter. They are more common in cardiovascular and cerebrovascular vessels. Rupture is one of the most dangerous complications. The pathophysiology of aneurysms is complex and diverse, often associated with progressive vessel wall dysfunction resulting from vascular smooth muscle cell (VSMC) death and abnormal extracellular matrix synthesis and degradation. Multiple studies have shown that long non-coding RNAs (lncRNAs) play a significant role in the progression of cardiovascular and cerebrovascular diseases. Therefore, it is necessary to find and summarize them. LncRNAs control gene expression and disease progression by regulating target mRNA or miRNA, and are biomarkers for the diagnosis and prognosis of aneurysmal cardiovascular and cerebrovascular diseases. This review explores the role, mechanism and clinical value of lncRNAs in aneurysms, providing new insights for a deeper understanding of the pathogenesis of cardiovascular and cerebrovascular aneurysms.

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长非编码 RNA 在血管平滑肌细胞表型及心脑血管动脉瘤发病机制中的作用

动脉瘤是血管的局部扩张，可扩张至原直径的 50%。它们在心脑血管中更为常见。破裂是最危险的并发症之一。动脉瘤的病理生理学复杂多样，通常与血管平滑肌细胞（VSMC）死亡、细胞外基质合成和降解异常导致的渐进性血管壁功能障碍有关。多项研究表明，长非编码 RNA（lncRNA）在心脑血管疾病的进展中起着重要作用。因此，有必要对其进行发现和总结。LncRNA 通过调控靶 mRNA 或 miRNA 来控制基因表达和疾病进展，是动脉瘤性心脑血管疾病诊断和预后的生物标志物。这篇综述探讨了 lncRNAs 在动脉瘤中的作用、机制和临床价值，为深入了解心脑血管动脉瘤的发病机制提供了新的见解。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.