Novel automated AIMLAM for diagnosis of Mycobacterium tuberculosis.

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-04-09 DOI:10.2217/fmb-2024-0025

Ruixia Liang, Jiankang Li, Hongmei Shi, Wu Han, Zhao Chang

引用次数: 0

Abstract

Aim: A rapid and precise diagnostic method is crucial for timely intervention and management of tuberculosis. The present study compared the diagnostic accuracy of a novel lipoarabinomannan (LAM) antigen test, AIMLAM, for tuberculosis in urine samples. Methodology: The study subjected 106 TB suspects to smear microscopy, MGIT, GeneXpert and AIMLAM. Results: Among 106, smear microscopy identified 36 as positive (33%) (sensitivity; 70.93%, 95% CI (60.14-80.22%), while MGIT showed 38 positive (36.8%). GeneXpert detected 59 positives (sensitivity; 96.83, 95% CI (89.00-99.61%)). AIMLAM declared 61 as positive (57.5%) (sensitivity; 100.00, 95% CI (94.13-100.00%) and 45 as negative (42.5%). Conclusion: Overall, AIMLAM demonstrated better diagnostic accuracy than GeneXpert Assay, smear microscopy and MGIT liquid culture in urine samples.

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用于诊断结核分枝杆菌的新型自动化 AIMLAM。

目的：快速准确的诊断方法对于及时干预和治疗结核病至关重要。本研究比较了新型脂联素甘露聚糖（LAM）抗原检测法 AIMLAM 对尿液样本中结核病的诊断准确性。研究方法研究对 106 名肺结核疑似患者进行涂片显微镜检查、MGIT、GeneXpert 和 AIMLAM 检测。结果：在 106 人中，涂片显微镜检查发现 36 人呈阳性（33%）（灵敏度为 70.93%，95% CI 为 60.14-80.22%），而 MGIT 检查显示 38 人呈阳性（36.8%）。GeneXpert 检测出 59 例阳性（灵敏度为 96.83%，95% CI 为 89.00-99.61%）。AIMLAM 宣布 61 例为阳性（57.5%）（灵敏度为 100.00，95% CI 为 94.13-100.00%），45 例为阴性（42.5%）。结论总体而言，在尿液样本中，AIMLAM 比 GeneXpert 分析、涂片显微镜检查和 MGIT 液体培养显示出更高的诊断准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.