Art, pharmacy and history of skin marking and surgical inks in plastic surgery

Tzong-Yang Pan, Irene Heng, Brian Sommerlad, Nicola R Dean
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Abstract

Plastic surgeons can be distinguished in pre-planning much of their surgery by drawing on the skin. The history of marking the body with ink in plastic surgery goes back to the 1400s. The Sommerlad pen was originally developed at the London Hospital in the 1970s. Sommerlad pens and Bonney’s blue ink allow for a consistent weight of the pen in hand, a reliable source of ink, and an ability to vary the thickness of the line drawn. There has been a suspicion that gentian violet, a component of Bonney’s blue ink, is a carcinogen, resulting in supply problems. Animal models have demonstrated the carcinogenic properties of gentian violet, but evidence to support the carcinogenic potential of gentian violet in humans is sparse. In the surgical setting, we must adhere to using published and described ink formulas. Proprietary formulations lack standardisation, and the compounds used are not always disclosed. The concerning findings of in-vitro and animal models are a valuable addition to our knowledge about these compounds; however, to over-extrapolate and restrict its use on humans as a topical skin marker takes away an important component of a plastic surgeon’s armamentarium.
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整形外科皮肤标记和手术墨水的艺术、药学和历史
整形外科医生通过在皮肤上作画来预先规划许多手术,可谓独树一帜。在整形手术中用墨水在身体上做标记的历史可以追溯到 1400 年代。Sommerlad 笔最初是 20 世纪 70 年代在伦敦医院开发的。Sommerlad 笔和邦尼的蓝色墨水可以使手中的笔重量一致,墨水来源可靠,并能改变所画线条的粗细。有人怀疑邦尼蓝墨水的成分龙胆紫是一种致癌物质,从而导致供应问题。动物模型已证明龙胆紫具有致癌特性,但支持龙胆紫对人类具有致癌可能性的证据却很少。在手术环境中,我们必须坚持使用已公布和描述的油墨配方。专有配方缺乏标准化,所使用的化合物也并不总是公开。体外和动物模型的相关研究结果为我们了解这些化合物提供了宝贵的资料;但是,如果过度推断并限制其在人体中作为局部皮肤标记物使用,就会使整形外科医生的武器装备失去一个重要的组成部分。
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